지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제16권 제3호
- 발행연도
- 2015.1
- 수록면
- 98 - 103 (6page)
이용수
초록· 키워드
오류제보하기
Tight junctions (TJs) form continuous intercellular contacts in intercellular junctions. TJs involve integral proteins such as occludin (OCLN) and claudins (CLDNs) as well as peripheral proteins such as zona occludens-1 (ZO-1) and junctional adhesion molecules (JAMs). TJs control paracellular transportation across cell-to-cell junctions. Although TJs have been studied for several decades, comparison of the transcriptional-translational levels of these molecules in canine organs has not yet been performed. In this study, we examined uterine expression of CLDNs, OCLN, junction adhesion molecule-A, and ZO-1 in canine. Expression levels of canine uterine TJ proteins, including CLDN1, 2, 4, 5, JAM-A, ZO-1, and OCLN, were measured using reverse transcription PCR, real-time PCR, and Western blotting, whereas TJs distribution was determined by immunohistochemistry. The mRNA and protein expression levels of OCLN, CLDN-1, 4, JAM-1, and ZO-1 were identified in the uterus. Immunohistochemistry demonstrated that TJs were localized to the endometrium and/or myometrium of the uterus. Our results show that canine TJ proteins, including CLDNs, OCLN, JAM-A, and ZO-1, were expressed in the canine uterus. Taken together, these proteins may perform unique physiological roles in the uterus. Therefore, these findings may serve as a basis for further studies on TJ proteins and their roles in the physiological or pathological condition of the canine uterus.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)]
Ando-Akatsuka Y / 1996 / Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues / J Cell Biol 133 : 43 ~ 47
Balda MS / 1996 / Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffu
Bazzoni G / 2003 / The JAM family of junctional adhesion molecules / Curr Opin Cell Biol 15 : 525 ~ 530
Fanning AS / 1999 / Transmembrane proteins in the tight junction barrier / J Am Soc Nephrol 10 : 1337 ~ 1345
Ando-Akatsuka Y / 1996 / Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues / J Cell Biol 133 : 43 ~ 47
Balda MS / 1996 / Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffu
Bazzoni G / 2003 / The JAM family of junctional adhesion molecules / Curr Opin Cell Biol 15 : 525 ~ 530
Fanning AS / 1999 / Transmembrane proteins in the tight junction barrier / J Am Soc Nephrol 10 : 1337 ~ 1345
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