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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한약침학회 Journal of Pharmacopuncture Journal of Pharmacopuncture 제13권 제2호
발행연도
2010.1
수록면
13 - 32 (20page)

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Objective : Bujeonghangam-tang(BH) has been used for cure of tumor as a traditional medicine. This study was carried out to clarify the effect of BH extract on hepatocellular carcinogenesis and hepatic cirrhosis induced by Diethylnitrosamine(DENA) and CCl4 in Rats. Method : Experimental groups were divided into two, 8th and 12th week groups, and subdivided into four; normal group(Nor), cirrhosis and hepatic cancer inducing control group(Con), and BH extract 320 ㎎/㎏/day(BHA) or 640 ㎎/㎏/day(BHB) administered groups to Con. Result :In the 8th week group: The body weight decreased significantly in Con compared with the Nor. The activities of transaminase, alkaline phosphatase(ALP), and lactacte dehydrogenase(LDH) were significantly increased(p<0.05) in the Con compared with Nor, but decreased in the BHA and BHB compared with Con. Alpha fetoprotein(AFP) were the most increased in the Con compared to BHA and BHB. The results of light microscopical observation, a number of hepatocytes were damaged in the Con compared with Nor and BH extract administerd groups. The number of hepatic p53 positive cells was reduced in the BH extract administered groups. According to the electron microscopical observation, hepatocarcinoma cells were observed distinctly in the Con compared with BH extract administered groups. In the 12 weeks group: The results of body were similar to 8th week groups. The activities of transaminase and ALT were significantly increased(p<0.05) in the Con compared with Nor. LDH was significantly(p<0.05) increased in the Con compared with Nor but significantly (p<0.05) decreased in the BHB. Alpha fetoprotein(AFP) were the most increased in the Con among experimental groups. The activities of superoxide dismutase(SOD) were significantly (p<0.05) increased in the Con, but the activities of catalase were not increased(p<0.05) compared with Nor. The number of hepatic p53 positive cells was increased in the Con. The results of electron microscopical observation were similar to 8th week groups. Conclusion : These results suggest that administration of BH extract suppress or retard DENA and CCl4-induced hepatocellular carcinogenesis and hepatic cirrhosis in rats.
#Bujeonghangam-tang #Hepatocellular Carcinogenesis #DENA #CCl4

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참고문헌 (36)

참고문헌 신청
Abdellatif, A. G / 1990 / Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxyacetic acid, perfluoro google schola Baek EK / 2003 / Anticancer Effect of Combination with Paljinhangahm-dan and Ariamycin on HepG2 Human / Malignant Hepatoma Cell Line 17 (5) : 1243 ~ 1250 google schola Beers RF Jr / 1952 / A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase / J Biol Chem. 195 (1) : 133 ~ 140 google schola Freeman, B. A / 1983 / Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevent oxygen injury / J. Bio. Chem. 258 : 12534 ~ 12542 google schola Gartel AL / 1996 / p21-negative regulator of the cell cycle / Proc. Soc. Exp. Biol. Med. 213 : 138 ~ 149 google schola

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