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자료유형
학술저널
저자정보
Kang, Kum-Suk (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) Kim, In-Deok (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) Kwon, Ryun-Hee (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University) Lee, Jin-Young (Department of Pharmaceutical Engineering, College of Engineering, Inje University) Kang, Jae-Seon (Department of Pharmaceutical Engineering, College of Engineering, Inje University) Ha, Bae-Jin (Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University)
저널정보
대한약학회 Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 제31권 제5호
발행연도
2008.1
수록면
622 - 627 (6page)

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The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against $CCl_4$-induced oxidative stress by monitoring the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Female, Sparague-Dowley rats were administered with FE (100 mg/kg daily) for 14 days and $CCl_4$ on the 15'th day, 12 h before they were sacrificed. The levels of GOT, GPT, ALP and LDH in serum of rats, as well as the levels of MDA, SOD, CAT and GPx in total liver homogenate were analyzed. $CCl_4$-treatment was found to increase the levels of GOT, GPT, ALP, LDH and MDA, as well as decrease levels of SOD, CAT and GPx significantly. The pre-treatment of rats with FE, however, suppressed the increment of levels of GOT, GPT, ALP, LDH and MDA, as well as recovered the levels of SOD, CAT and GPx in CCl4-treated rats. Moreover there was a significant decrease in incidences of necrosis and cirrhosis in the liver tissue of FE-treated rats. These results implied that FE possessed antioxidant properties against $CCl_4$-induced oxidative stress.

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