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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 13 - 20 (8page)
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In this study, the effects of Ganoderma lucidum (GL) on fat metabolism were performed in 3T3-L1 adipocytes.
The effects of GL on 3T3-L1 preadipocytes differentiation were also examined. Our results showed that GL decreased the TG content by ORO staining. To elucidate the mechanism of the effects of GL on lowering TG content in 3T3-L1 adipocytes, we examined whether GL modulate the expressions of transcription factors and adipokines related to control of energy expenditure process because adipokines regulate adipocyte mass and increased expenditure may consume much TG in adipocytes.
As a result, the expression of C/EBPβ, C/EBPδ, C/EBPα, and PPARγ genes, which induce the adipose differentiation and adipose-specific FAS, aP2, and adipsin genes, which compose fat formation were decreased. In addition, GL increased the expression of leptin, UCP2, adiponectin in 3T3-L1 adipocytes, resulting in energy homeostasis.
In conclusion, GL could regulate transcript factor related to induction of adipose differentiation and control TG content by up-regulation of adipokines related to fat burn.
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참고문헌 (25)
참고문헌 신청
Ahima RS, F.J. / 2000 / Adipose tissue as an endocrine organ / Trends Endocrinol Metab. 11 (8) : 327 ~ 332
Antuna-Puente B, F.B. / 2008 / Adipokines: the missing link between insulin resistance and obesity / Diabetes Metab. 34 (1) : 2 ~ 11
Berg AH, C.T. / 2001 / The adipocyte-secreted protein Acrp30 enhances hepatic insulin action / Nat Med. 7 (8) : 945 ~ 953
Camp HS, R.D. / 2002 / Adipogenesis and fat-cell function in obesity and diabetes / Trends Mol Med. 8 (9) : 442 ~ 447
Ceddia RB, W.W.J / 2000 / Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes / Eur
Antuna-Puente B, F.B. / 2008 / Adipokines: the missing link between insulin resistance and obesity / Diabetes Metab. 34 (1) : 2 ~ 11
Berg AH, C.T. / 2001 / The adipocyte-secreted protein Acrp30 enhances hepatic insulin action / Nat Med. 7 (8) : 945 ~ 953
Camp HS, R.D. / 2002 / Adipogenesis and fat-cell function in obesity and diabetes / Trends Mol Med. 8 (9) : 442 ~ 447
Ceddia RB, W.W.J / 2000 / Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes / Eur
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