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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제14권 제1호
- 발행연도
- 2015.1
- 수록면
- 31 - 38 (8page)
이용수
초록· 키워드
오류제보하기
Background and Purpose The one-day rivastigmine patch is reportedly well tolerated and has minimal side effects. However, Asian patientsshow more side effects than those in Western countries. We evaluated tolerability of the rivastigmine patch in South Korean patientswith Alzheimer’s disease (AD) and the specific factors affecting adverse events of the skin.
Methods A 6-month, open labeled, multi-centered, observational study was carried out in 440 patients with probable AD from July 2009to September 2010 (NCT01312363).
Results A total of 25.9% of the patients experienced adverse skin events at the rivastigmine patch application site and 17.0% discontinuedtreatment due to adverse events at the skin application site. The most common adverse events were itching and erythema. Patients with an allergichistory and users of electric heating appliances reported skin discomfort. Older age was associated with discontinuing treatment.
Conclusions These results suggest that the rivastigmine patch induced some adverse skin events and may contribute to understanding andimproving skin tolerability to the rivastigmine patch.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Gauthier S / 2013 / Real-life effectiveness and tolerability of the rivastigmine transdermal patch in patients with mild-to-moderate Alzheimer’s disease:the EMBRACE study / Curr Med Res Opin 29:989~1000
Segers K / 2012 / Do local meteorological conditions influence skin irritation caused by transdermal rivastigmine? A retroprospective, pilot study / J Clin Psychopharmacol 32:412~415
Upadhye MR / 1992 / Influence of area of application of allergen on sensitization in contact dermatitis / Contact Dermatitis 27:281~286
Hurkmans JF / 1985 / Skin irritation caused by transdermal drug delivery systems during long-term (5 days) application / Br J Dermatol 112:461~467
Ale I / 2009 / Skin tolerability associated with transdermal drug delivery systems: an overview / Adv Ther 26:920~935
Segers K / 2012 / Do local meteorological conditions influence skin irritation caused by transdermal rivastigmine? A retroprospective, pilot study / J Clin Psychopharmacol 32:412~415
Upadhye MR / 1992 / Influence of area of application of allergen on sensitization in contact dermatitis / Contact Dermatitis 27:281~286
Hurkmans JF / 1985 / Skin irritation caused by transdermal drug delivery systems during long-term (5 days) application / Br J Dermatol 112:461~467
Ale I / 2009 / Skin tolerability associated with transdermal drug delivery systems: an overview / Adv Ther 26:920~935
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