지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 57 - 68 (12page)
이용수
초록· 키워드
오류제보하기
Objective : This study was performed to evaluate the effect of Lithospermum erythrorhizon extracts on the inflammatory cytokines gene expression by the bacteria of Propionibacterium acnes (P. acnes) which elicits acne in human monocytes, THP-1 cell line.
Experiment : Cytotoxicity of Lithospermum erythrorhizon extracts was analyzed by XTT assay. Real time RT-PCR was applied to analyze the cytokines gene expressions of IL-8, MCP-1 and TNF-α. Translocation of transcription factor NF-κB from cytoplasm into nucleus was observed using immunocytochemistry and confocal microscopy.
Results : Lithospermum erythrorhizon extracts did not show cytotoxicity as high as in 1,000 ㎍/㎖ of concentration. Transcription levels of inflammatory cytokines, IL-8, MCP-1 and TNF-α were increased by P.
acnes in THP-1 and Lithospermum erythrorhizon extracts decreased the upregulated transcription levels.
Lithospermum erythrorhizon extracts significantly inhibited the translocation of NF-κB into nucleus by P. acnes.
Conclusion : This study suggests that Lithospermum erythrorhizon extracts have anti-inflammatory effects on P. acnes treated THP-1 as decreasing the mRNA expressions of IL-8, MCP-1 and TNF-α. This anti-inflammatory effect of Lithospermum erythrorhizon extracts may be useful in therapeutic treatments for acne vulgaris
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Chen Q / 2002 / Propionibacterium acne-induced IL-8 production may be mediated by NF-κB activation in human monocytes / J Dermatol Sci 29 : 97 ~ 103
Hou,Y / 2006 / Effect of Shikonin on Human Breast Cancer Cells Proliferation and Apoptosis In Vitro / Yakugaku Zasshi 126 : 1383 ~ 1386
Ishida, T / 2007 / Protection of Human Kerationcytes from UVB-Induced Inflammation Using Root Extract of Lithospermum erythrorhizon / Bio. Pharm. Bull 30 : 928 ~ 934
Kim SH / 2001 / Antitumor activities fo a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33 / Cancer Lett 172 (2) : 171 ~ 175
Vowles BR / 1995 / Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne / Infect Immunity 63 : 31
Hou,Y / 2006 / Effect of Shikonin on Human Breast Cancer Cells Proliferation and Apoptosis In Vitro / Yakugaku Zasshi 126 : 1383 ~ 1386
Ishida, T / 2007 / Protection of Human Kerationcytes from UVB-Induced Inflammation Using Root Extract of Lithospermum erythrorhizon / Bio. Pharm. Bull 30 : 928 ~ 934
Kim SH / 2001 / Antitumor activities fo a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33 / Cancer Lett 172 (2) : 171 ~ 175
Vowles BR / 1995 / Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne / Infect Immunity 63 : 31
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
紫草가 HaCaT 세포의 사이토카인 유전자 발현에 미치는 영향
한방안이비인후피부과학회지
2013 .01
-
Effects of Lithospermum Erythrorhizon on immobile behavior and Immune Changes in the Forced Swimming Test
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Single- and Repeat-dose Oral Toxicity Studies of Lithospermum erythrorhizon Extract in Dogs
Toxicological Research
2015 .03
-
Psychosocial Aspects of Acne Vulgaris: A Community-based Study with Korean Adolescents
Annals of Dermatology
2009 .01
-
Cryptotanshinone for Treating Acne Vulgaris
대한화장품학회지
2002 .01
-
여드름의 치료예후에 영향을 미치는인자들에 대한 상관성 고찰
한방안이비인후피부과학회지
2008 .01
-
Efficacy of Bacteriophages in Propionibacterium acnes-Induced Inflammation in Mice
Annals of Dermatology
2019 .01
-
Propionylshikonin form the Roots of Lithospermum erythrorhizon
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
-
紫草가 항알러지 염증반응에 미치는 영향
대한한의학회지
2005 .09
-
Anxiety Sensitivity and Quality of Life in Patients with Acne
Annals of Dermatology
2019 .01
-
G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes
Annals of Dermatology
2017 .01
-
四象 處方으로 치료한 여드름 환자 81례의 臨床報告
한방안이비인후피부과학회지
2009 .01
-
A Correlation between Serum Level of Alkaline Phosphatase and Acne Severity in Children and Adolescents: A Retrospective Cross-Sectional Study
Annals of Dermatology
2020 .01
-
여드름의 東·西醫學的 文獻 考察
한방안이비인후피부과학회지
2012 .01
-
Alexithymia and Acne Vulgaris: A Case Control Study
PSYCHIATRY INVESTIGATION
2011 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0