지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 62 - 75 (14page)
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초록· 키워드
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Objective : The purpose of this study is to examine the effects of Gamisipjeontang-gamibang(GT) on an
experimental burn elicitation.
Method : The absorbance of the photo cell mixed with GT at the Abs 560 ㎚ was measured after
irradiation for 1 min. In order to know the antioxidant effect on skin cell of mice after burn elicitation,
superoxide dismutase(SOD) activity was measured.
Also, in order to know effects on the skin regeneration in the burned mice, we counted the eosinophil in
blood from animals via cardiac puncture and observed the histological structure in the epidermal basal layer
and the dermal section on the 3rd, 7th and 14th day after burn elicitation. We also studied changes in
angiogenesis in the capillary surrounding the basal layer and dermal papilla. The changes of HSP70
distribution and changes of p53 positive reaction were observed to investigate the changes of the stress in
the skin as well.
Result : The results indicated that GT has a significant impact on the antioxidant effect on skin cells of
mice after burn elicitation by increasing SOD activity in vitro test. GT seems to decrease MIP-2 which
induces neutrophil infiltration and promotes the angiogenesis dose-dependently. Furthermore, GT decreased
HSP70, the expression of which was induced by elevated temperatures, and p53 which induce a apoptosis
after stress.
Conclusion : GT can be applied to burned skin through its antioxidant effect and skin regeneration
property.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Chiarelli A / 1990 / Veri early nutrition supplementation in burned paitents / Am J Clin Nutr 51 : 1035 ~ 1039
De Maio A / 1995 / The heat-shock response / New Horiz 2 : 198 ~ 207
G. Multhoff / 2007 / Heat shock protein 70 (HSP70): Membrane location, export and immunological relevance / Methods 43 : 229 ~
Gianotti O / 1994 / Post injury hypermetabolic response and magnitude of translocation : prevention by early enternal nutrition / Nutrition 3 : 225 ~ 231
Saito H / 1987 / The effect of route of nutrient administration on the nutritional state, catabolic hormone secretion, and gut mucosal integrity after burn injury / J Parente
De Maio A / 1995 / The heat-shock response / New Horiz 2 : 198 ~ 207
G. Multhoff / 2007 / Heat shock protein 70 (HSP70): Membrane location, export and immunological relevance / Methods 43 : 229 ~
Gianotti O / 1994 / Post injury hypermetabolic response and magnitude of translocation : prevention by early enternal nutrition / Nutrition 3 : 225 ~ 231
Saito H / 1987 / The effect of route of nutrient administration on the nutritional state, catabolic hormone secretion, and gut mucosal integrity after burn injury / J Parente
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