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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,545 - 1,551 (7page)
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초록· 키워드
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Purpose: Elastin is a major arterial structural protein, and elastin-derived peptides are related to arterial change. We previously reported on a novel assay developed using aortic elastin peptides; however, its clinical implications remain unclear. In this study, we assessed whether anti-elastin antibody titers reflect the risk of coronary artery disease (CAD) or its characteristics.
Materials and Methods: We included 174 CAD patients and 171 age- and sex-matched controls. Anti-elastin antibody titers were quantified by enzyme-linked immunosorbent assay. Parameters of arterial stiffness, including the augmentation index (AI) and heart-to-femoral pulse wave velocity (hfPWV), were measured non-invasively. The clinical and angiographic characteristics of CAD patients were also evaluated. Associations between anti-elastin levels and vascular characteristics were examined by linear regression analysis.
Results: The median blood level of anti-elastin was significantly lower in the CAD group than in the controls [197 arbitrary unit (a.u.) vs. 63 a.u., p<0.001]. Levels of anti-elastin were significantly lower in men and in subjects with hypertension, diabetes mellitus,hyperlipidemia, or high hfPWV. Nevertheless, anti-elastin levels were not dependent on atherothrombotic events or the angiographicseverity of CAD. In a multivariate analysis, male sex (β=-0.38, p<0.001), diabetes mellitus (β=-0.62, p<0.001), hyperlipidemia(β=-0.29, p<0.001), and AI (β=-0.006, p=0.02) were ultimately identified as determinants of anti-elastin levels.
Conclusion: Lower levels of anti-elastin are related to CAD. The association between antibody titers and CAD is linked to arterial stiffness rather than the advancement of atherosclerosis.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Atanasova M / 2010 / Age-related changes of anti-elastin antibodies in senescence-accelerated mice / Gerontology 56 : 310 ~ 318
Baydanoff S / 1987 / Age-related changes in antielastin antibodies in serum from normal and atherosclerotic subjects / Atherosclerosis 63 : 267 ~ 271
Baydanoff S / 1987 / Age-related changes in the level of circulating elastin-derived peptides in serum from normal and atherosclerotic subjects / Atherosclerosis 66 : 163 ~ 1
Cheng XW / 2011 / Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications / Hypertension 58 : 978 ~ 986
Fulop T Jr / 1990 / Determination of elastin peptides in normal and arteriosclerotic human sera by ELISA / Clin Physiol Biochem 8 : 273 ~ 282
Baydanoff S / 1987 / Age-related changes in antielastin antibodies in serum from normal and atherosclerotic subjects / Atherosclerosis 63 : 267 ~ 271
Baydanoff S / 1987 / Age-related changes in the level of circulating elastin-derived peptides in serum from normal and atherosclerotic subjects / Atherosclerosis 66 : 163 ~ 1
Cheng XW / 2011 / Cysteine protease cathepsins in atherosclerosis-based vascular disease and its complications / Hypertension 58 : 978 ~ 986
Fulop T Jr / 1990 / Determination of elastin peptides in normal and arteriosclerotic human sera by ELISA / Clin Physiol Biochem 8 : 273 ~ 282
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