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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,582 - 1,589 (8page)
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초록· 키워드
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Purpose: The association between liver enzymes and death from external causes has not been examined. We investigated the associationbetween serum aminotransferase levels and external-cause mortality in a large prospective cohort study.
Materials and Methods: A total of 142322 subjects of 35–59 years of age who completed baseline examinations in 1990 and 1992 were enrolled. Mortalities were identified using death certificates. Serum alanine aminotransferase (ALT) and aspartate aminotransferase(AST) levels were categorized into quintiles. Sub-distribution hazards ratios and 95% confidence intervals (CIs) were estimated using a competing risks regression model in which deaths from other causes were treated as competing risks.
Results: Of 8808 deaths, 1111 (12.6%) were due to external causes. Injury accounted for 256 deaths, and suicide accounted for 255. After adjusting for covariates, elevated ALT and AST were significantly associated with an increased risk of all external-cause mortalities,as well as suicide and injury. Sub-distribution hazards ratios (95% CIs) of the highest versus the lowest quintiles of serum ALT and AST were, respectively, 1.57 (1.26–1.95) and 1.45 (1.20–1.76) for all external causes, 2.73 (1.68–4.46) and 1.75 (1.15–2.66) for suicide, and 1.79 (1.10–2.90) and 1.85 (1.21–2.82) for injury. The risk of external-cause mortality was also significantly higher in the fourth quintile of ALT (21.6–27.5 IU/L) than in its first quintile.
Conclusion: Elevated aminotransferase levels, even within the normal range, were significantly associated with increased risk of all external-cause mortalities, including suicide, and injury.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Anstee QM / 2013 / Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis / Nat Rev Gastroenterol Hepatol 10 : 330 ~ 344
Armstrong MJ / 2012 / Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort / J Hepatol 56 : 234 ~ 240
Chen CH / 2007 / Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan / J Gastroenterol Hepatol 22 : 1482 ~ 1489
Chobanian AV / 2003 / The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report / JAMA
Clark JM / 2003 / The prevalence and etiology of elevated aminotransferase levels in the United States / Am J Gastroenterol 98 : 960 ~ 967
Armstrong MJ / 2012 / Presence and severity of non-alcoholic fatty liver disease in a large prospective primary care cohort / J Hepatol 56 : 234 ~ 240
Chen CH / 2007 / Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan / J Gastroenterol Hepatol 22 : 1482 ~ 1489
Chobanian AV / 2003 / The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report / JAMA
Clark JM / 2003 / The prevalence and etiology of elevated aminotransferase levels in the United States / Am J Gastroenterol 98 : 960 ~ 967
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