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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 721 - 728 (8page)
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Replication of the hepatitis B virus is suppressed by deficiency of the X protein. Although several molecules that block cellular targets of X protein reduce the production of hepatitis B virus progeny, the effect of a specific inhibitor of X protein on viral replication has not been investigated. To block X protein specifically, we adopted an intracellular expression approach using H7 single chain variable fragment (H7scFv), an antibody fragment against X protein. We previously demonstrated that cytoplasmic expression of H7scFv inhibits X protein-induced tumorigenicity and transactivation. In this study, intracellular H7scFv expression inhibits reporter gene transactivation but not viral replication determined by endogenous hepatitis B virus polymerase activity assay and real-time PCR. Our findings imply that intracellular expression of antibody fragment against X protein may not be an alternative therapeutic modality for inhibition of hepatitis B virus replication.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ / Hepatitis B virus cancer 1988 : 61 ~
/ / Intracellular antibodies as a new class of therapeutic molecules for gene therapy : 595 ~ 601
/ / The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells : 617 ~ 21
/ 1995 / The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors 14 : 4747 ~ 4757
/ 1996 / Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinase
/ / Intracellular antibodies as a new class of therapeutic molecules for gene therapy : 595 ~ 601
/ / The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells : 617 ~ 21
/ 1995 / The hepatitis B virus HBx protein is a dual specificity cytoplasmic activator of Ras and nuclear activator of transcription factors 14 : 4747 ~ 4757
/ 1996 / Hepatitis B virus HBx protein induces transcription factor AP-1 by activation of extracellular signal-regulated and c-Jun N-terminal mitogen-activated protein kinase
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