지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Viral hepatitis is the inflammation of liver cells caused by viruses, and still one of the major health-care problems worldwide. A number of viruses to cause hepatitis are type A, B, C, D, E or G. Among these viruses leading to hepatitis, B and C are more troublesome being more prone to chronic illness which can cause the potentially fatal conditions of hepatocellular carcinoma (HCC) and/or liver failure. If immediate treatment is not initiated, liver transplant is the only option left. Over the past few decades there has been remarkable progress in diagnose and monitor all hepatitis virus infections for treatment and prevention. Nonetheless, important challenges remain to develop more effective and safe vaccines for prevention as well as antiviral agents to reduce viremia/viral load by inhibiting viral replication. The development and evaluation of antiviral agents through carefully designed clinical trials over the last 25 years has heralded a new dawn in the treatment of patients chronically infected with the hepatitis B and C viruses, but not so for the D virus. The introduction of Direct Acting Antivirals (DDAs) for the treatment of HBV carriers has permitted the long term use of these compounds for the continuous suppression of viral replication. This review aims to summarize the current status and development approaches of antiviral drugs for the treatment of viral hepatitis and future perspectives.
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참고문헌 (67)
참고문헌 신청
HB El-Serag / 2012 / Epidemiology of viral hepatitis and hepatocellular carcinoma / Gastroenterology 142:1264
Karayiannis, P / 2012 / Direct Acting Antivirals for the treatment of chronic viral hepatitis / Scientifica Review :1
2005 / European Pharmacopoeia 5.0 / Hepatitis A Vaccine (inactivated, adsorbed)
Pevion Biotech Ltd / Virosomal Vaccine Plaftforms
Christian Moser / 2003 / Ian C Metcalfe and Jean-Franois Viret : Virosomal adjuvant antigen delivery systems / Expert Reviews Vaccine 2:189
Karayiannis, P / 2012 / Direct Acting Antivirals for the treatment of chronic viral hepatitis / Scientifica Review :1
2005 / European Pharmacopoeia 5.0 / Hepatitis A Vaccine (inactivated, adsorbed)
Pevion Biotech Ltd / Virosomal Vaccine Plaftforms
Christian Moser / 2003 / Ian C Metcalfe and Jean-Franois Viret : Virosomal adjuvant antigen delivery systems / Expert Reviews Vaccine 2:189
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