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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 165 - 172 (8page)
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Purpose: Reduced brain glucose metabolism and basal forebrain cholinergic neuron degeneration are common features of Alzheimer’sdisease and have been correlated with memory function. Although regions representing glucose hypometabolism inpatients with Alzheimer’s disease are targets of cholinergic basal forebrain neurons, the interaction between cholinergic denervationand glucose hypometabolism is still unclear. The aim of the present study was to evaluate glucose metabolism changescaused by cholinergic deficits.
Materials and Methods: We lesioned basal forebrain cholinergic neurons in rats using 192 immunoglobulin G-saporin. After 3weeks, lesioned animals underwent water maze testing or were analyzed by 18F-2-fluoro-2-deoxyglucose positron emission tomography.
Results: During water maze probe testing, performance of the lesioned group decreased with respect to time spent in the targetquadrant and platform zone. Cingulate cortex glucose metabolism in the lesioned group decreased, compared with the normalgroup. Additionally, acetylcholinesterase activity and glutamate decarboxylase 65/67 expression declined in the cingulate cortex.
Conclusion: Our results reveal that spatial memory impairment in animals with selective basal forebrain cholinergic neurondamage is associated with a functional decline in the GABAergic and cholinergic system associated with cingulate cortex glucosehypometabolism.
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참고문헌 (23)
참고문헌 신청
Bierer LM / 1995 / Neurochemical correlates of dementia severity in Alzheimer’s disease: relative importance of the cholinergic deficits / J Neurochem 64 : 749 ~ 760
Bigl V / 1982 / Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: a combined fluorescent tracer and acetylc
Browne SE / 2001 / Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits
Burgess N / 2002 / The human hippocampus and spatial and episodic memory / Neuron 35 : 625 ~ 641
Croxson PL / 2011 / Cholinergic modulation of a specific memory function of prefrontal cortex / Nat Neurosci 14 : 1510 ~ 1512
Bigl V / 1982 / Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: a combined fluorescent tracer and acetylc
Browne SE / 2001 / Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits
Burgess N / 2002 / The human hippocampus and spatial and episodic memory / Neuron 35 : 625 ~ 641
Croxson PL / 2011 / Cholinergic modulation of a specific memory function of prefrontal cortex / Nat Neurosci 14 : 1510 ~ 1512
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