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NGF and HB-EGF: Potential Biomarkers that Reflect the Effects of Fesoterodine in Patients with Overactive Bladder Syndrome
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논문 기본 정보

Type
Academic journal
Author
Journal
Yonsei University College of Medicine Yonsei Medical Journal Yonsei Medical Journal 제56권 제1호 KCI Accredited Journals
Published
2015.1
Pages
204 - 211 (8page)

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NGF and HB-EGF: Potential Biomarkers that Reflect the Effects of Fesoterodine in Patients with Overactive Bladder Syndrome
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Purpose: To determine whether levels of nerve growth factor (NGF) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) can be used to objectively assess overactive bladder syndrome (OAB) treatment outcome and to evaluate the effects of fixed-dose fesoterodine on OAB symptoms. Materials and Methods: This study included 124 participants (62 patients with OAB and 62 controls) in Severance Hospital between 2010 and 2012. In patients with OAB, 4 mg fesoterodine was administered once daily. Repeated evaluations of putative biomarker levels, urine creatinine (Cr) levels, and questionnaire responses,including the Overactive Bladder Symptom Score (OABSS) and the OveractiveBladder Questionnaire (OAB q), were performed from baseline to 16 weeks. Results: Urinary levels of NGF/Cr (OAB: 1.13±0.9 pg/mg; control: 0.5±0.29 pg/mg) and HB-EGF/Cr (OAB: 8.73±6.55 pg/mg; control: 4.45±2.93 pg/mg) were significantly higher in subjects with OAB than in controls (p<0.001). After 16 weeks of fixed-dose fesoterodine treatment, urinary NGF/Cr levels (baseline: 1.13±0.08 pg/mg; 16 weeks: 0.60±0.4 pg/mg; p=0.02) and HB-EGF/Cr levels significantly decreased (baseline: 8.73±6.55 pg/mg; 16 weeks: 4.72±2.69 pg/mg; p=0.03, respectively). Both the OABSS and OAB q scores improved (p<0.001). However, there were no a statistically significant correlations between these urinarymarkers and symptomatic scores. Conclusion: Urinary levels of NGF and HB-EGF may be potential biomarkers for evaluating outcome of OAB treatment. Fixed-dose fesoterodine improved OAB symptoms. Future studies are needed to further examine the significance of urinary NGF and HB-EGF levels as therapeuticmarkers for OAB.
#Heparin-binding EGF-like growth factor #nerve growth factor #overactive bladder #questionnaire #urinary biomarkers

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References (22)

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Abrams P / 2000 / Overactive bladder significantly affects quality of life / Am J Manag Care 6 (11 Suppl) : S580 ~ S590 google schola Abrams P / 2009 / Incontinence. 4th International Consultation on Incontinence / Health Publication Ltd. google schola Candela JV / 1998 / Evaluation of urinary IL-1alpha and IL-1beta in gravid females and patients with bacterial cystitis and microscopic hematuria / Urol Res 26 : 175 ~ 180 google schola Coyne K / 2002 / Psychometric validation of an overactive bladder symptom and health-related quality of life questionnaire: the OAB-q / Qual Life Res 11 : 563 ~ 574 google schola Erickson DR / 2008 / Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome / J Urol 179 : 1850 ~ 1856 google schola

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