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Voltage is an important parameter that regulates the conductance of both intercellularand plasma membrane channels (undocked hemichannels) formed by the 21 members of the mammalian connexin gene family. Connexin channels display two forms of voltage-dependence, rectification of ionic currents and voltage-dependentgating. Ionic rectification results either from asymmetries in the distributionof fixed charges due to heterotypic pairing of different hemichannels, or by channel block, arising from differences in the concentrations of divalent cations on opposite sides of the junctional plaque. This rectification likely underpins the electricalrectification observed in some electrical synapses. Both intercellular and undockedhemichannels also display two distinct forms of voltage-dependent gating, termed Vj (fast)-gating and loop (slow)-gating. This review summarizes our currentunderstanding of the molecular determinants and mechanisms underlying these conformational changes derived from experimental, molecular-genetic, structural, and computational approaches.
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참고문헌 (26)
참고문헌 신청
Abrams CK / 2013 / Functional requirement for a highly conserved charged residue at position 75 in the gap junction protein connexin 32 / J Biol Chem 288 : 3609 ~ 3619
Abrams CK / 2014 / GJB1-associated X-linked Charcot-Marie-Tooth disease, a disorder affecting the central and peripheral nervous systems / Cell Tissue Res
Auerbach AA / 1969 / A rectifying electrotonic synapse in the central nervous system of a vertebrate / J Gen Physiol 53 : 211 ~ 237
Bai D, / 2014 / Extracellular domains play different roles in gap junction formation and docking compatibility / Biochem J 458 : 1 ~ 10
Bauer R / 2005 / Intercellular communication: the Drosophila innexin multiprotein family of gap junction proteins / Chem Biol 12 : 515 ~ 526
Abrams CK / 2014 / GJB1-associated X-linked Charcot-Marie-Tooth disease, a disorder affecting the central and peripheral nervous systems / Cell Tissue Res
Auerbach AA / 1969 / A rectifying electrotonic synapse in the central nervous system of a vertebrate / J Gen Physiol 53 : 211 ~ 237
Bai D, / 2014 / Extracellular domains play different roles in gap junction formation and docking compatibility / Biochem J 458 : 1 ~ 10
Bauer R / 2005 / Intercellular communication: the Drosophila innexin multiprotein family of gap junction proteins / Chem Biol 12 : 515 ~ 526
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