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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,227 - 1,234 (8page)
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초록· 키워드
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Purpose: Primary vascular dysregulation (PVD) is a condition in which the response to cold temperature or external stimuli is abnormal. We investigated whether triflusal use results in amelioration of PVD symptoms and improvement of several related parameters compared with aspirin.
Materials and Methods: Eighty-eight PVD patients (54% female, 56±8 years) were randomly selected to receive either triflusal (300 mg, b.i.d.) or aspirin (150 mg, b.i.d.) for a period of 6 weeks followed by crossover. PVD was defined as both red-blood-cell standstill in video-assisted microscopic capillaroscopy during cold stimulation using carbon dioxide gas and a score of more than 7 points in a validated questionnaire. Efficacy of treatment was assessed by 1) cold intolerance symptom severity (CISS) score, 2) finger Dopplerindices, and 3) indocyanine green perfusion imaging.
Results: The use of triflusal resulted in a greater improvement in CISS score (44.5±18.4 vs. 51.9±16.2; p<0.001) and in mean radial peak systolic velocity (69.8±17.2 vs. 66.1±16.4; p=0.011) compared to aspirin. Furthermore, significant differences were also observedin perfusion rates on indocyanine green perfusion imaging between triflusal and aspirin (45.6±25.8 vs. 51.6±26.9; p=0.020).
Conclusion: Triflusal was more effective and demonstrated a more consistent impact on the improvement of symptoms and blood flow in patients with PVD than aspirin.
목차
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참고문헌 (24)
참고문헌 신청
Belch J / 1997 / Raynaud’s phenomenon / Cardiovasc Res 33 : 25 ~ 30
Campia U / 2002 / Role of cyclooxygenase products in the regulation of vascular tone and in the endothelial vasodilator function of normal, hypertensive, and hypercholesterol
Cruz-Fernandez JM / 2000 / Randomized comparative trial of triflusal and aspirin following acute myocardial infarction / Eur Heart J 21 : 457 ~ 465
De La Cruz JP / 1995 / Effects of triflusal and its main metabolite HTB on platelet interaction with subendothelium in healthy volunteers / Eur J
De Miguel LS / 2000 / A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils:role in platelet function / Eur J Clin
Campia U / 2002 / Role of cyclooxygenase products in the regulation of vascular tone and in the endothelial vasodilator function of normal, hypertensive, and hypercholesterol
Cruz-Fernandez JM / 2000 / Randomized comparative trial of triflusal and aspirin following acute myocardial infarction / Eur Heart J 21 : 457 ~ 465
De La Cruz JP / 1995 / Effects of triflusal and its main metabolite HTB on platelet interaction with subendothelium in healthy volunteers / Eur J
De Miguel LS / 2000 / A 4-trifluoromethyl derivative of salicylate, triflusal, stimulates nitric oxide production by human neutrophils:role in platelet function / Eur J Clin
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