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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,288 - 1,295 (8page)
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Purpose: In this study, we aimed to evaluate whether nonalcoholic fatty liver disease (NAFLD) was associated with the presence and morphology of coronary atherosclerotic plaques shown by multidetector computed tomography (MDCT) in asymptomatic subjects without a history of cardiovascular disease.
Materials and Methods: We retrospectively enrolled 772 consecutive South Korean individuals who had undergone both dual-source 64-slice MDCT coronary angiography and hepatic ultrasonography during general routine health evaluations. The MDCT studies were assessed for the presence, morphology (calcified, mixed, and non-calcified), and severity of coronary plaques.
Results: Coronary atherosclerotic plaques were detected in 316 subjects (40.9%) by MDCT, and NAFLD was found in 346 subjects (44.8%) by hepatic ultrasonography. Subjects with NAFLD had higher prevalences of all types of atherosclerotic plaque and non-calcified, mixed, and calcified plaques than the subjects without NAFLD. However, the prevalence of significant stenosis did not differbetween groups. After adjusting for age, smoking status, diabetes mellitus, hypertension, dyslipidemia, and metabolic syndrome, NAFLD remained a significant predictor for all types of coronary atherosclerotic plaque [odds ratio (OR): 1.48; 95% confidence interval(CI): 1.05–2.08; p=0.025] in binary logistic analysis, as well as for calcified plaques (OR: 1.70; 95% CI: 1.07–2.70; p=0.025) in multinomial regression analysis.
Conclusion: Our study demonstrated that NAFLD was significantly associated with the presence and the calcified morphology of coronary atherosclerotic plaques detected by MDCT. Further prospective clinical studies are needed to clarify the exact physiopathologicrole of NAFLD in coronary atherosclerosis.
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참고문헌 (20)
참고문헌 신청
Abdulla J / 2011 / Prognostic value of absence or presence of coronary artery disease determined by 64-slice computed tomography coronary angiography a systematic review and
Adams LA / 2005 / The natural history of nonalcoholic fatty liver disease:a population-based cohort study / Gastroenterology 129 : 113 ~ 121
Adibi P / 2007 / Prediction of coronary atherosclerotic disease with liver transaminase level / Liver Int 27 : 895 ~ 900
Agatston AS / 1990 / Quantification of coronary artery calcium using ultrafast computed tomography / J Am Coll Cardiol 15 : 827 ~ 832
Austen WG / 1975 / A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Ca
Adams LA / 2005 / The natural history of nonalcoholic fatty liver disease:a population-based cohort study / Gastroenterology 129 : 113 ~ 121
Adibi P / 2007 / Prediction of coronary atherosclerotic disease with liver transaminase level / Liver Int 27 : 895 ~ 900
Agatston AS / 1990 / Quantification of coronary artery calcium using ultrafast computed tomography / J Am Coll Cardiol 15 : 827 ~ 832
Austen WG / 1975 / A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Ca
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