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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 175 - 188 (14page)
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초록· 키워드
오류제보하기
Nicotine, the primary psychoactive component of tobacco products, produces diverse neurophysiological, motivational, and behavioral effects through several brain regions and neurochemical pathways. Various neurotransmitter systems have been explored to understand the mechanisms behind nicotine tolerance, dependence, and withdrawal. Recent evidence suggests that glutamate neurotransmission has an important role in this phenomenon. The aim of the present review is to discuss preclinical findings concerning the role of N-methyl-D-aspartate (NMDA) receptor neurotransmission in mediating the behavioral effects of nicotine, tolerance, sensitization, dependence, and withdrawal. Based on preclinical findings, it is hypothesized that NMDA receptors mediate the common adaptive processes that are involved in the development, maintenance, and expression of nicotine addiction. Modulation of glutamatergic neurotransmission with NMDA receptor antagonists may prove to be useful in alleviating the symptoms of nicotine abstinence and facilitate tobacco-smoking cessation.
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등록된 정보가 없습니다.
참고문헌 (162)
참고문헌 신청
Corrigall WA / 1989 / Evidence for a behavioral deficit during withdrawal from chronic nicotine treatment / Pharmacol Biochem Behav 33:559~562
Balfour DJ / 1990 / A comparison of the effects of nicotine and (+) amphetamine on rat behaviour in an unsignalled Sidman avoidance schedule / J Pharm Pharmacol 42:257~260
Costall B / 1989 / Exploration of mice in a black and white test box: validation as a model of anxiety / Pharmacol Biochem Behav 32:777~785
Sorenson EM / 1998 / Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat / Neuroscience 87:659~673
Fung YK / 1988 / Receptor mechanisms of nicotine- induced locomotor hyperactivity in chronic nicotine- treated rats / Eur J Pharmacol 152:263~271
Balfour DJ / 1990 / A comparison of the effects of nicotine and (+) amphetamine on rat behaviour in an unsignalled Sidman avoidance schedule / J Pharm Pharmacol 42:257~260
Costall B / 1989 / Exploration of mice in a black and white test box: validation as a model of anxiety / Pharmacol Biochem Behav 32:777~785
Sorenson EM / 1998 / Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat / Neuroscience 87:659~673
Fung YK / 1988 / Receptor mechanisms of nicotine- induced locomotor hyperactivity in chronic nicotine- treated rats / Eur J Pharmacol 152:263~271
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