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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,511 - 1,516 (6page)
이용수
초록· 키워드
오류제보하기
The quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) has been introduced for military recruits in Korea since 2012. This study was performed to evaluate the immunogenicity of MenACWY-CRM in Korean military recruits. In addition, the influence of tetanus-diphtheria toxoids (Td) vaccination on the vaccine response to MenACWY-CRM was analyzed. A total of 75 military recruits were enrolled. Among them, 18 received a dose of MenACWY-CRM only (group 1), and 57 received Td three days before MenACWY-CRM immunization (group 2). The immunogenicity of MenACWY-CRM was compared between the two groups. The serum bactericidal activity with baby rabbit complement was measured before and three weeks after immunization against serogroups A, C, W-135, and Y. The geometric mean titers (GMTs) against four serogroups were significantly increased in both groups after immunization. Compared to group 2, group 1 exhibited significantly higher vaccine responses in several aspects:post-immune GMTs against serogroup A and C, seroresponse rates against serogroup A, and a fold increases of titers against serogroup A, C, and Y. MenACWY-CRM was immunogenic against all vaccine-serogroups in Korean military recruits. Vaccine response to MenACWY-CRM was influenced by Td administered three days earlier.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Harrison LH / 2001 / Invasive meningococcal disease in adolescents and young adults / JAMA 286:694~699
Rosenstein NE / 2001 / Meningococcal disease / N Engl J Med 344:1378~1388
Thompson MJ / 2006 / Clinical recognition of meningococcal disease in children and adolescents / Lancet 367:397~403
Agrawal S / 2011 / Acute bacterial meningitis in infants and children: epidemiology and management / Paediatr Drugs 13:385~400
Broderick MP / 2012 / Trends in meningococcal disease in the United States military, 1971-2010 / Emerg Infect Dis 18:1430~1437
Rosenstein NE / 2001 / Meningococcal disease / N Engl J Med 344:1378~1388
Thompson MJ / 2006 / Clinical recognition of meningococcal disease in children and adolescents / Lancet 367:397~403
Agrawal S / 2011 / Acute bacterial meningitis in infants and children: epidemiology and management / Paediatr Drugs 13:385~400
Broderick MP / 2012 / Trends in meningococcal disease in the United States military, 1971-2010 / Emerg Infect Dis 18:1430~1437
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