지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,106 - 1,113 (8page)
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Purpose: Although the applications of adipose tissue-derived cells (ADCs) in regenerativemedicine have been investigated, the role of ADCs in fracture healing remains unclear. In this study, we examined the fracture-healing effects and survival of transplanted ADCs using micro-computed tomography (CT) and bioluminescenceimaging (BLI). Materials and Methods: Luciferase-expressing ADCs were suspended in solubilized basement membrane preparation (SBMP) and xenografted on defects in the right femur of nude mice (n=5). SBMP alone was grafted on a defectin the contralateral femur. Serial in vivo micro-CT and BLI were performed for 20 days. Ex vivo BLI images of both femurs were obtained. Differences in the Hounsfieldunit (HU), HUratio, and luciferase activities were compared using Wilcoxon signed-rank tests and non-parametric longitudinal analyses (p<0.05). Results: In vivo BLI revealed a signal drop on day 2, reconstitution on day 5, and continuous decrement thereafter. Ex vivo BLI revealed residual activity in the ADC-implanted and adjacent areas. No activity was detected in the contralateral femur. The overall increment rate of normalized HUs was higher for ADC-treated femurs than for SBMP-treated femurs. Cell migration to distant injury sites was not detected. Conclusion:Enhanced bone density in the implant area suggests that ADCs have fracture-healing effects.
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참고문헌 (20)
참고문헌 신청
Bielby R / 2007 / The role of mesenchymal stem cells in maintenance and repair of bone / Injury 38 (Suppl 1) : S26 ~ S32
Bigham-Sadegh A / 2014 / Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures / Int Wound J
Brighton CT / 1995 / Tibial nonunion treated with direct current, capacitive coupling, or bone graft / Clin Orthop Relat Res : 223 ~ 234
Bruder SP / 1998 / Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells / J Orthop Res 16 : 155 ~ 162
Bruder SP / 1998 / Mesenchymal stem cells in osteobiology and applied bone regeneration / Clin Orthop Relat Res 355 (Suppl) : S247 ~ S256
Bigham-Sadegh A / 2014 / Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures / Int Wound J
Brighton CT / 1995 / Tibial nonunion treated with direct current, capacitive coupling, or bone graft / Clin Orthop Relat Res : 223 ~ 234
Bruder SP / 1998 / Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells / J Orthop Res 16 : 155 ~ 162
Bruder SP / 1998 / Mesenchymal stem cells in osteobiology and applied bone regeneration / Clin Orthop Relat Res 355 (Suppl) : S247 ~ S256
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