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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 598 - 607 (10page)
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Purpose: The aims of this study were to compare the expression of sarcosine metabolism-related proteins between invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and to determine the implications of these results. Materialsand Methods: Tissue microarrays were constructed, containing 30 samples from normal breast tissue, 114 samples from patients with ILC, and 692 samples from patients with IDC. Immunohistochemical staining was performed to examine the expression of sarcosine metabolism-related proteins [glycine N-methyltransferase,sarcosine dehydrogenase, and l-pipecolic acid oxidase (PIPOX)]. Results: The sarcosine metabolic phenotype differed between ILC and IDC (p<0.001). In IDC, sarcosine metabolic phenotype was distributed as null type (61.7%)>low sarcosine type (30.4%)>high sarcosine type (5.0%)>intermediate type (2.9%). However, in ILC, the sarcosine metabolic phenotype was distributed as low sarcosine type (61.4%)>null type (32.5%)>intermediate type (5.3%)>high sarcosine type (0.9%). PIPOX showed higher expression in ILC than in IDC (p<0.001) and correlated with androgen receptor (AR) positivity (p=0.001) in ILC. Conclusion: Expression of sarcosine metabolism-related proteins differed between ILC and IDC. Low sarcosinetype was the majority sarcosine metabolic phenotype of ILC. PIPOX expressionwas predominant in ILC and correlated with AR positivity.
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참고문헌 (21)
참고문헌 신청
Baum CE / 2010 / Sarcosine as a potential prostate cancer biomarker and therapeutic target / Cancer Biol Ther 9 : 341 ~ 342
De Leeuw WJ / 1997 / Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ / J Pathol 183 : 404 ~ 411
Elston CW / 1991 / Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow
Goldhirsch A / 2011 / Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therap
Hammond ME / 2010 / American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progeste
De Leeuw WJ / 1997 / Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ / J Pathol 183 : 404 ~ 411
Elston CW / 1991 / Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow
Goldhirsch A / 2011 / Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therap
Hammond ME / 2010 / American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progeste
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