지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 339 - 344 (6page)
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초록· 키워드
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Purpose: Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability. The objective of the study is to assess the relationship between carotid intima-media thickness (IMT) and atherosclerotic risk factors. Materials and Methods: Twentyseven PWS children and 24 normal controls were enrolled. Correlations of IMT with atherosclerotic risk factors were assessed. Results: IMTs in the PWS group did not differ from those in the controls (p = 0.172), although total ghrelin levels were higher in the PWS children (p = 0.003). The multivariate analysis revealed positive correlations between total ghrelin levels ( = 0.489, p = 0.046) and IMT in the PWS group and between body mass indexstandard deviation score (BMI-SDS) ( = 0.697, p = 0.005) and IMT in the controls. Conclusion: Considering the positive correlation of IMT with total ghrelin levels and the high level of ghrelin in PWS children, a further study is warranted to evaluate the role of elevated ghrelin on atherosclerosis for PWS.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Ariyasu H / 2001 / Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans / J Clin Endocrinol M
Choe YH / 2005 / Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome / J Clin Endocrinol Metab 90 : 5441 ~ 5445
Cummings DE / 2001 / A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans / Diabetes 50 : 1714 ~ 1719
DelParigi A / 2002 / High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome / J Clin Endocrinol Metab 87 : 5461 ~ 5464
Geroulakos G / 1994 / Carotid intima-media thickness: correlation with the British Regional Heart Study risk score / J Intern Med 235 : 431 ~ 433
Choe YH / 2005 / Increased density of ghrelin-expressing cells in the gastric fundus and body in Prader-Willi syndrome / J Clin Endocrinol Metab 90 : 5441 ~ 5445
Cummings DE / 2001 / A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans / Diabetes 50 : 1714 ~ 1719
DelParigi A / 2002 / High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome / J Clin Endocrinol Metab 87 : 5461 ~ 5464
Geroulakos G / 1994 / Carotid intima-media thickness: correlation with the British Regional Heart Study risk score / J Intern Med 235 : 431 ~ 433
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