지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 459 - 471 (13page)
이용수
초록· 키워드
오류제보하기
Purpose: This study examined the expression and function of inward rectifier K+ channels in cultured rat hepatic stellate cells (HSC). Materials and Methods: The expression of inward rectifier K+ channels was measured using real-time RT-PCR, and electrophysiological properties were determined using the gramicidin-perforated patch-clamp technique. Results: The dominant inward rectifier K+ channel subtypes were Kir2.1 and Kir6.1. These dominant K+ channel subtypes decreased significantly during the primary culture throughout activation process. HSC can be classified into two subgroups: one with an inward-rectifying K+ current (type 1) and the other without (type 2). The inward current was blocked by Ba2+ (100μM) and enhanced by high K+ (140mM), more prominently in type 1 HSC. There was a correlation between the amplitude of the Ba2+-sensitive current and the membrane potential. In addition, Ba2+ (300μM) depolarized the membrane potential. After the culture period, the amplitude of the inward current decreased and the membrane potential became depolarized. Conclusion: HSC express inward rectifier K+ channels, which physiologically regulate membrane potential and decrease during the activation process. These results will potentially help determine properties of the inward rectifier K+ channels in HSC as well as their roles in the activation process.
목차
등록된 정보가 없습니다.
참고문헌 (51)
참고문헌 신청
Doupnik CA / 1995 / The inward rectifier potassium channel family / Curr Opin Neurobiol 5:268~277
Jan LY / 1997 / Voltage-gated and inwardly rectifying potassium channels / J Physiol 505:267~282
Nichols CG / 1997 / rectifier potassium channels / Annu Rev Physiol 59:171~191
Gutman GA / 2003 / International Union of Pharmacology. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels / Pharmacol Rev 55:583~586
이건일 / 2004 / Characteristics of Postassium and Calcium Currents of Hepatic Stellate Cells (Ito) in Male Rat / Yonsei Medical Journal 45(4):649~660
Jan LY / 1997 / Voltage-gated and inwardly rectifying potassium channels / J Physiol 505:267~282
Nichols CG / 1997 / rectifier potassium channels / Annu Rev Physiol 59:171~191
Gutman GA / 2003 / International Union of Pharmacology. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels / Pharmacol Rev 55:583~586
이건일 / 2004 / Characteristics of Postassium and Calcium Currents of Hepatic Stellate Cells (Ito) in Male Rat / Yonsei Medical Journal 45(4):649~660
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Characteristics of Postassium and Calcium Currents of Hepatic Stellate Cells (Ito) in Male Rat
Yonsei Medical Journal
2004 .01
-
Gene Expression Profiles During the Activation of Rat Hepatic Stellate Cells Evaluated by cDNA Microarray
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2007 .01
-
Influence of Glibenclamide on Catecholamine Secretion in the Isolated Rat Adrenal Gland
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2007 .01
-
Influence of Apamin on Catecholamine Secretion from the Rat Adrenal Medulla
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2002 .01
-
Expression of osteopontin and this role in hepatic stellate cell motility and wound healing migration
대한약학회 학술대회
2003 .01
-
Identification of Expressed Sequence Tags of Genes Expressed Highly in the Activated Hepatic Stellate Cell
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2004 .01
-
Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis
Clinical and Molecular Hepatology
2015 .01
-
Effect of Rhus verniciflua strokes acetone extracts and its components on the proliferation, collagen synthesis, and hepatic fibrosis related proteins mRNA levels in rat hepatic stellate cells
대한약학회 학술대회
2003 .01
-
Expression of O-acetyl disialoganglioside synthase in experimental rat and human liver fibrosis
대한약학회 학술대회
2003 .01
-
Honokiol induces apoptosis in activated rat hepatic stellate cells via cytochrome c release and caspase activation
대한약학회 학술대회
2003 .01
-
miR-140-3p Knockdown Suppresses Cell Proliferation and Fibrogenesis in Hepatic Stellate Cells via PTEN-Mediated AKT/mTOR Signaling
Yonsei Medical Journal
2019 .01
-
간성상세포의 활성에서 siRNA를 이용한 TGF-β1의 전사조절
Journal of Pathology and Translational Medicine
2009 .01
-
The autophagy Protein Atg5 Plays a Crucial Role in the Maintenance and Reconstitution Ability of Hematopoietic Stem Cells
Immune Network
2019 .04
-
Effects of Conjugated Linoleic Acid (CLA) Isomer, t10c12, c9tll-CLA and Mixed Form on Rat Hepatic Stellate Cells (HSC-T6) and Hepatic Fibrosis
한국수의병리학회 학술발표논문집
2004 .01
-
Heterogeneous Composition of Voltage-Dependent K(+) Currents in Hepatic Stellate Cells
Yonsei Medical Journal
2007 .01
-
The Identification of HSC70 as a Biomarker for Copper Exposure in Medaka Fish
Environmental Analysis Health and Toxicology
2007 .09
-
白屈菜가 간섬유화 과정 중 간성상세포에 미치는 영향
대한한방내과학회지
2011 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0