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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 366 - 371 (6page)
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Purpose: The aim of this study was to evaluate the changes of the regulatory T cell subset in peripheral blood caused by gestational age and premature rupture of membranes (PROM) with or without labor to verify the role of regulatory T cells in pregnancy. Patients and Methods: We investigated regulatory T cell distribution in the peripheral blood of pregnancies during the first trimester (group I, n=2), the second trimester (group II, n=12), and the third trimester without PROM and labor (group III, n=15). In addition, we evaluated pregnancies in the third trimester complicated by PROM (group IV, n= 4) and labor with no complication by PROM (Group V, n= 5). Comparisons were made with non-pregnant controls (group VI, n=4) using flow cytometry. Results: During uncomplicated pregnancy, the CD4+CD25bright regulatory T cell population decreased with advancing gestational age (group I=3.35±0.47, group II=2.91±1.44, group III=2.81 ±1.36, group VI=2.52±0.71, p=NS). When we compared group IV with group III and V to evaluate the changes of the regulatory T cells with PROM, the CD4+CD25bright regulatory T cell population was significantly decreased in group IV compared to group III (p=0.001) and group V (p=0.026). Conclusion: The present results revealed that the regulatory T cell population increased in early pregnancy but decreased in pregnancies complicated by PROM, indicating that regulatory T cells might be related to the maintenance of pregnancy.
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참고문헌 (19)
참고문헌 신청
Aluvihare VR / 2004 / Regulatory T cells mediate maternal tolerance to the fetus / Nat Immunol 5 : 266 ~ 271
Baecher-Allan C / 2001 / CD4+CD25high regulatory cells in human peripheral blood / J Immunol 167 : 1245 ~ 1253
Gervasi MT / 2002 / Maternal intravascular inflammation in preterm premature rupture of membranes / J Matern Fetal Neonatal Med 11 : 171 ~ 175
Gomez R / 1995 / Premature labor and intra-amniotic infection. Clinical aspects and role of the cytokines in diagnosis and pathophysiology / Clin Perinatol 2 : 281 ~ 342
Graca L / 2002 / Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance / J Immunol 168 : 5558 ~ 5565
Baecher-Allan C / 2001 / CD4+CD25high regulatory cells in human peripheral blood / J Immunol 167 : 1245 ~ 1253
Gervasi MT / 2002 / Maternal intravascular inflammation in preterm premature rupture of membranes / J Matern Fetal Neonatal Med 11 : 171 ~ 175
Gomez R / 1995 / Premature labor and intra-amniotic infection. Clinical aspects and role of the cytokines in diagnosis and pathophysiology / Clin Perinatol 2 : 281 ~ 342
Graca L / 2002 / Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance / J Immunol 168 : 5558 ~ 5565
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