지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 193 - 199 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaCentral 5-HT1A receptor is involved in the modulation of sensorimotor gating function. However, its precise role is not clearly defined in developmentally social deprived (isolation rearing, IR) rats featured with impaired sensorimotor gating ability. We therefore aimed to examine the effects of 5HT1A activation on acoustic startle response (ASR) and prepulse inhibition (PPI) in IR rats in a condition of compromised presynaptic 5-HT functions. MethodsaaSocial control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletor, 5,7-DHT. Seven days later rats entered a protocol of 8-OH-DPAT, a 5-HT1A agonist, in which locomotor activity, ASR and PPI and their tissue levels of 5-HT were measured. ResultsaaOur results found that both IR and 5,7-DHT decreased the tissue concentration of 5-HT. IR-induced hyperactivity and gating impairment were unaffected by 5-HT depletion. 8-OH-DPAT strengthened the ASR in IR but not SOC rats and the drug-reduced PPI could be adjusted by 5,7-DHT pretreatment. 8-OH-DPAT at 100 μg/kg enhanced PPI in 5-HT-depleted SOC rats. However for IR rats, 8-OH-DPAT strengthened PPI in sham rats but downgraded it in depletion condition. ConclusionaaThe integrity of central 5-HT system is important to 5-HT1A-modulated sensorimotor gating in isolation-reared rats.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Nanry KP / 1989 / The role of 5HT1A receptors in the modulation of the acoustic startle reflex in rats / Psychopharmacology (Berl) 97:507~513
Rigdon GC / 1992 / 5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex / J Pharmacol Exp Ther 263:486~493
Sipes TA / 1995 / 8-OH-DPAT disruption of prepulse inhibition in rats: reversal with (+)WAY 100,135 and localization of site of action / Psychopharmacology (Berl) 117:41~48
Muller CP / 2007 / Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors / Prog Neurobiol 81:133~178
Fletcher PJ / 2001 / Reduced brain serotonin activity disrupts prepulse inhibition of the acoustic startle reflex. Effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine / Neuropsychopharmacology 24:399~409
Rigdon GC / 1992 / 5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex / J Pharmacol Exp Ther 263:486~493
Sipes TA / 1995 / 8-OH-DPAT disruption of prepulse inhibition in rats: reversal with (+)WAY 100,135 and localization of site of action / Psychopharmacology (Berl) 117:41~48
Muller CP / 2007 / Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors / Prog Neurobiol 81:133~178
Fletcher PJ / 2001 / Reduced brain serotonin activity disrupts prepulse inhibition of the acoustic startle reflex. Effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine / Neuropsychopharmacology 24:399~409
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