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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 949 - 954 (6page)
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Purpose: To determine whether insulin-like growth factor (IGF-1) affects transforming growth factor (TGF-β)- mediated fibronectin accumulation in human lens epithelial cell line (HLE B-3) cells. Materials and Methods: HLE B-3 cells were incubated for 24 hours with TGF-β (10ng/ mL), IGF-1 (10ng/mL), or both. Expression of the fibronectin gene was determined using a real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Fibronectin levels were examined using western blot analysis and immunofluorescence staining. Results: Expression of the fibronectin gene was not different between the TGF-β/IGF-1 treated group and the TGF-β treated group (p= 0.116). However, western blot analysis demonstrated decreased fibronectin levels in human lens epithelial cells treated with TGF-β and IGF-1 compared to those treated with TGF-β only (p<0.01). Immunofluorescence staining disclosed inhibition of TGF-β-induced fibronectin in the presence of IGF-1. Conclusion: This study suggests that IGF-1 counteracts TGF-β-mediated fibronectin accumulation in human lens epithelial cells.
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참고문헌 (18)
참고문헌 신청
Andley UP / 1994 / Propagation and immortalization of human lens epithelial cells in culture 35 : 3094 ~ 3102
Chung SH / 2006 / Impact of short- term exposure of commercial eyedrops preserved with benzalkonium chloride on precorneal mucin 12 : 415 ~ 421
Cobo LM / / George G. Pathogenesis of capsular opacification after extracapsular cataract extraction : 857 ~ 63
Daian T / 2003 / Insulin-like growth factor-I enhances transforming growth factor-beta- induced extracellular matrix protein production through the P38/activating transcript
Font RL / / Brownstein S. A light and electron microscopic study of anterior subcapsular cataracts. Am J Ophthalmol 1974 : 972 ~ 84
Chung SH / 2006 / Impact of short- term exposure of commercial eyedrops preserved with benzalkonium chloride on precorneal mucin 12 : 415 ~ 421
Cobo LM / / George G. Pathogenesis of capsular opacification after extracapsular cataract extraction : 857 ~ 63
Daian T / 2003 / Insulin-like growth factor-I enhances transforming growth factor-beta- induced extracellular matrix protein production through the P38/activating transcript
Font RL / / Brownstein S. A light and electron microscopic study of anterior subcapsular cataracts. Am J Ophthalmol 1974 : 972 ~ 84
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