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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 164 - 170 (7page)
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초록· 키워드
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The purpose of the present study was to discuss the effects of risedronate on osteoarthritis (OA) of the knee by reviewing the existing literature. The literature was searched with PubMed, with respect to prospective, double-blind,randomized placebo-controlled trials (RCTs), using the following search terms: risedronate, knee, and osteoarthritis.
Two RCTs met the criteria. A RCT (n = 231) showed that risedronate treatment (15 mg/day) for 1 year improved symptoms. A larger RCT (n = 1,896) showed that risedronate treatment (5 mg/day, 15 mg/day, 35 mg/week, and 50mg/week) for 2 years did not improve signs or symptoms, nor did it alter radiological progression. However, a subanalysis study (n = 477) revealed that patients with marked cartilage loss preserved the structural integrity of subchondral bone by risedronate treatment (15 mg/day and 50 mg/week). Another subanalysis study (n = 1,885)revealed that C-terminal crosslinking telopeptide of type II collagen (CTX-II) decreased with risedronate treatment in a dose-dependent manner, and levels reached after 6 months were associated with radiological progression at 2 years.
The results of these RCTs show that risedronate reduces the marker of cartilage degradation (CTX-II), which could contribute to attenuation of radiological progression of OA by preserving the structural integrity of subchondral bone.
The review of the literature suggests that higher doses of risedronate (15 mg/day) strongly reduces the marker of cartilage degradation (CTX-II), which could contribute to attenuation of radiological progression of OA by preserving the structural integrity of subchondral bone.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Altman R / 1986 / Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Cr
Bellamy N / 1988 / Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patien
Bendele AM / 1988 / Spontaneous cartilage degeneration in guinea pigs / Arthritis Rheum 31 : 561 ~ 565
Bettica P / 2002 / Evidence for increased bone resorption in patients with progressive knee osteoarthritis:longitudinal results from the Chingford study / Arthritis Rheum 46
Bingham CO 3rd / 2006 / Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with me
Bellamy N / 1988 / Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patien
Bendele AM / 1988 / Spontaneous cartilage degeneration in guinea pigs / Arthritis Rheum 31 : 561 ~ 565
Bettica P / 2002 / Evidence for increased bone resorption in patients with progressive knee osteoarthritis:longitudinal results from the Chingford study / Arthritis Rheum 46
Bingham CO 3rd / 2006 / Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with me
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