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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 458 - 465 (8page)
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이 논문의 연구 히스토리 (3)
2012
The Effects of Intra-articular Platelet-Rich Plasma Injection According to the Severity of Collagenase-Induced Knee Osteoarthritis in a Rabbit Model
권동락
,
박기영
한국실험동물학회 학술발표대회 논문집
2012.08
학술대회자료
The Effects of Intra-Articular Platelet-Rich Plasma Injection According to the Severity of Collagenase-Induced Knee Osteoarthritis in a Rabbit Model
권동락
,
Sung-uk Lee
,
박기영
Annals of Rehabilitation Medicine
2012.01
학술저널
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초록· 키워드
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Objective To investigate whether the cartilage regenerative effects of intra-aricular platelet-rich plasma (PRP) are different, according to the severity of osteoarthritis (OA), in a collagenase-induced knee OA rabbit model.Method New Zealand white rabbits (N=21) were randomly divided into three groups. Three different doses (0.25 mg, group 1; 0.5 mg, group 2; and 1.0 mg, group 3) of collagenase were injected twice into both knees of each group under an ultrasound guidance. The mean platelet concentration of the PRP fraction was 2,664±970×103/μl and was enriched 8.2-times, compared with the whole blood. PRP (0.3 ml) was injected into the left knee and saline (0.3 ml) into the right knee at 4 weeks, and macroscopic and histological scores of both injected knees were evaluated at 9 weeks after the first collagenase injection.Results Macroscopic and histological scores of group 3 were significantly higher than those of group 1 and 2 (p<0.05). Macroscopic and histological scores of the PRP-injected knees were significantly lower than those of the saline-injected knees, in all groups (p<0.05). Differences of gross morphologic and histologic scores between sa-line- and PRP-injected knees in group 3 were significantly higher than those in group 1 and 2 (p<0.05).Conclusion Intra-articular PRP injection influences cartilage regeneration in all severities of rabbit knee OA, and the cartilage regenerative power of PRP injection in moderate knee OA was greater than that in mild or very mild OA. A large preclinical trial is needed to establish the validity of our study.
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참고문헌 (22)
참고문헌 신청
Akeda K / 2006 / Plateletrich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis / Osteoarthritis Cartilage 14 : 1272 ~ 1280
Altman R / 1996 / Design and conduct of clinical trials in patients with osteoarthritis: recommendations from a task force of the Osteoarthritis Research Society. Results fro
Anitua E / 2006 / New insights into and novel applications for platelet-rich fibrin therapies / Trends Biotechnol 24 : 227 ~ 234
Anitua E / 2007 / Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthr
Cunnington J / 2010 / A randomized, double-blind, controlled study of ultrasound-guided corticosteroid injection into the joint of
Altman R / 1996 / Design and conduct of clinical trials in patients with osteoarthritis: recommendations from a task force of the Osteoarthritis Research Society. Results fro
Anitua E / 2006 / New insights into and novel applications for platelet-rich fibrin therapies / Trends Biotechnol 24 : 227 ~ 234
Anitua E / 2007 / Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthr
Cunnington J / 2010 / A randomized, double-blind, controlled study of ultrasound-guided corticosteroid injection into the joint of
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