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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,139 - 1,144 (6page)
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초록· 키워드
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Purpose: Patients with gout are similar to those with bacterial infection in terms of the nature of inflammation. Herein we comparedthe differences in procalcitonin (PCT) levels between these two inflammatory conditions and evaluated the ability of serum PCTto function as a clinical marker for differential diagnosis between acute gouty attack and bacterial infection.
Materials and Methods: Serum samples were obtained from 67 patients with acute gouty arthritis and 90 age-matched patientswith bacterial infection. Serum PCT levels were measured with an enzyme-linked fluorescent assay.
Results: Serum PCT levels in patients with acute gouty arthritis were significantly lower than those in patients with bacterial infection(0.096±0.105 ng/mL vs. 4.94±13.763 ng/mL, p=0.001). However, erythrocyte sedimentation rate (ESR) and C-reactive protein(CRP) levels showed no significant differences between the two groups. To assess the ability of PCT to discriminate between acutegouty arthritis and bacterial infection, the areas under the curves (AUCs) of serum PCT, uric acid, and CRP were 0.857 [95% confidenceinterval (CI), 0.798–0.917, p<0.001], 0.808 (95% CI, 0.738–0.878, p<0.001), and 0.638 (95% CI, 0.544–0.731, p=0.005), respectively.
There were no significant differences in ESR and white blood cell counts between these two conditions. With a cut-off valueof 0.095 ng/mL, the sums of sensitivity and specificity of PCT were the highest (81.0% and 80.6%, respectively).
Conclusion: Serum PCT levels were significantly lower in patients with acute gouty attack than in patients with bacterial infection.
Thus, serum PCT can be used as a useful serologic marker to differentiate between acute gouty arthritis and bacterial infections.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Hershfield MS / 2009 / Reassessing serum urate targets in the management of refractory gout: can you go too low? / Curr Opin Rheumatol 21:138~142
Mehanic S / 2013 / The importance of serum procalcitonin in diagnosis and treatment of serious bacterial infections and sepsis / Mater Sociomed 25:277~281
Hyuck Lee / 2013 / Procalcitonin as a biomarker of infectious diseases / The Korean Journal of Internal Medicine 28(3):285
Uzzan B / 2006 / Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis / Crit Care Med 34:1996~2003
Nijsten MW / 2000 / Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro / Crit Care Med 28:458~461
Mehanic S / 2013 / The importance of serum procalcitonin in diagnosis and treatment of serious bacterial infections and sepsis / Mater Sociomed 25:277~281
Hyuck Lee / 2013 / Procalcitonin as a biomarker of infectious diseases / The Korean Journal of Internal Medicine 28(3):285
Uzzan B / 2006 / Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis / Crit Care Med 34:1996~2003
Nijsten MW / 2000 / Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro / Crit Care Med 28:458~461
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