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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 69 - 77 (9page)
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Purpose: The urodynamic effects of intravesical PGE2 instillation on bladder function and detrusor overactivity (DO) during the filling phase were investigated in rats by measuring intraabdominal and intravesical pressures simultaneously.
Materials and Methods: Continuous cystometry was performed inconscious, female and male Sprague- Dawley rats. We investigated pressure-, volume-, and DO-related parameters.
Results: Intravesical instillation of PGE2 increased all pressure-related parameters and decreased volume-related ones, compared to the control cystometric ones. However, among the total number of intravesical pressure rises (IVPRs) above 2 cmH2O during the filling phase, only 33% in female rats and 38% in male rats after PGE2 instillation were identified as true DO during the filling phase.
Conclusions: Our findings suggest that the rat model with intravesical PGE2 is inappropriate for observing the effects of some drugs or mechanisms on DO, because only approximately 30% of IVPRs were confirmed as true DO. However, this model of intravesical PGE2 instillation has some advantages for the observation of changes in pressure and volume parameters rather than in DO-related ones.
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참고문헌 (16)
참고문헌 신청
Abrams P / 2002 / The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society /
Andersson KE / 1999 / Advances in the pharmacological control of the bladder / Exp Physiol 84 : 195 ~ 213
Andersson KE / 2004 / Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence / Pharmacol Rev 56 : 581 ~ 631
Brading AF / 1997 / A myogenic basis for the overactive bladder / Urology 50 : 57 ~ 67
Christ GJ / 2003 / Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo / Am J Physiol Regul Integr Comp Physiol 284 : R12
Andersson KE / 1999 / Advances in the pharmacological control of the bladder / Exp Physiol 84 : 195 ~ 213
Andersson KE / 2004 / Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence / Pharmacol Rev 56 : 581 ~ 631
Brading AF / 1997 / A myogenic basis for the overactive bladder / Urology 50 : 57 ~ 67
Christ GJ / 2003 / Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo / Am J Physiol Regul Integr Comp Physiol 284 : R12
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