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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 358 - 366 (9page)
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초록· 키워드
오류제보하기
Severe acute alcoholic liver disease (SAAH) unresponsive to medical therapy shows one-year-mortality rates of up to 90%. Most transplant centers request six months of alcohol abstinence prior to transplantation, the so-called “6-month rule.” This regulation is not based on strong evidence, repeatedly making it a topic of controversial debates. The majority of patients with SAAH will die before fulfilling the 6-month rule. Therefore, liver transplantation (LT) protocols are becoming more flexible towards the rigid abstinence regulation, especially concerning SAAH patients. We conducted a literature review regarding LT in SAAH and its outcomes, including post-transplant mortality and recidivism. We studied available data on PubMed from 2011 and onwards whilst including articles dealing with genetic components, medical therapy and historic snapshots of alcoholism. Emerging studies recommend LT in SAAH not responding to medical therapies even without realizing the required abstinence period, since the majority of these patients would die within 6 months. SAAH without response to medical therapy has one-year-mortality rates of up to 90%. The 6-month rule is not based on strong evidence and is repeatedly a topic of controversial debates. There is genetic linkage to alcoholism and medical therapy is not as effective as estimated, yet. The 6-months-regulation has not shown to evidently decrease the risk of recidivism post-LT, which is a lifesaving treatment in SAAH patients. Insisting on rigid sobriety rules results in excluding patients with a low risk of recidivism from being transplanted. Moreover, the genetic linkage of alcoholism must be recognized.
목차
등록된 정보가 없습니다.
참고문헌 (85)
참고문헌 신청
Testino G / 2008 / Alcoholic diseases in hepato-gastroenterology : a point of view / Hepatogastroenterology 55:371~377
Crawford JM / 2010 / Vascular disorders of the liver / Clin Liver Dis 14:635~650
European Association for the Study of Liver / 2012 / EASL clinical practice guidelines : management of alcoholic liver disease / J Hepatol 57:399~420
Sohail U / 2012 / Diagnosis and management of alcoholic hepatitis / Clin Liver Dis 16:717~736
Mathurin P / 2011 / Early liver transplantation for severe alcoholic hepatitis / N Engl J Med 365:1790~1800
Crawford JM / 2010 / Vascular disorders of the liver / Clin Liver Dis 14:635~650
European Association for the Study of Liver / 2012 / EASL clinical practice guidelines : management of alcoholic liver disease / J Hepatol 57:399~420
Sohail U / 2012 / Diagnosis and management of alcoholic hepatitis / Clin Liver Dis 16:717~736
Mathurin P / 2011 / Early liver transplantation for severe alcoholic hepatitis / N Engl J Med 365:1790~1800
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