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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 35 - 39 (5page)
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Azathioprine is commonly used as immunosuppressive therapy for various inflammatory diseases including chronic glomerulonephritis. Myelosuppression is a common side effect of azathioprine, resulting in the need for dose reduction.
However, severe pancytopenia or alopecia is not often encountered. Here, we report a case of severe myelosuppression, and alopecia totalis that occurred after azathioprine treatment in a patient with IgA nephropathy. A 10-year-old boy with IgA nephropathy was treated with oral deflazacort and later with azathioprine.
After 4 weeks, the patient complained of hair loss, and despite a dose reduction in azathioprine, he developed bone marrow suppression and alopecia totalis in two weeks. The blood indices and alopecia of the patient had returned to normal after azathioprine withdrawal and 3 consecutive doses of granulocyte colony-stimulating factor. We suggest that physicians remain vigilant to the side effects of azathioprine.
Unusual hair loss after azathioprine treatment might suggest a defect in the metabolism of the drug, warranting the discontinuation of azathioprine to prevent more severe side effects.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Anstey A / 1992 / Pancytopenia related to azathioprine--an enzyme deficiency caused by a common genetic polymorphism: a review / Journal of the Royal Society of Medicine 85 :
Collie-Duguid E / 1999 / The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations / Pharmacogenetics and Genomics 9 : 37 ~ 42
Derijks L / 2006 / Review article:thiopurines in inflammatory bowel disease / Alimentary pharmacology & therapeutics 24 : 715 ~ 729
DiPiero J / 2015 / Should thiopurine methyltransferase (TPMT) activity be determined before prescribing azathioprine, mercaptopurine, or thioguanine? / Cleveland Clinic jour
Gearry RB / 2005 / Azathioprine and 6?mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease / Journal of gastroenterology and hepatology 20
Collie-Duguid E / 1999 / The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations / Pharmacogenetics and Genomics 9 : 37 ~ 42
Derijks L / 2006 / Review article:thiopurines in inflammatory bowel disease / Alimentary pharmacology & therapeutics 24 : 715 ~ 729
DiPiero J / 2015 / Should thiopurine methyltransferase (TPMT) activity be determined before prescribing azathioprine, mercaptopurine, or thioguanine? / Cleveland Clinic jour
Gearry RB / 2005 / Azathioprine and 6?mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease / Journal of gastroenterology and hepatology 20
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