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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 239 - 244 (6page)
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Mycobacterium tuberculosis (M. tuberculosis) complex is the causative agent of tuberculosis (TB) in hu-mans and bovine TB in mammalian hosts and grows very slowly. Selenium is a central molecule in nitrogen metabolism and an essential ingredient for all living cells and glutamic acid. The effects of selenium on the growth of M. tuberculosis, a representative slow-growing Mycobacterium species, were investigated and measured using the BacT Alert 3D System (MB/BacT System). Sodium selenate, at a final concentration of 10 g/mL, reduced the average time-to detection (TTD) to 197.2 hours (95% confidence interval (CI), 179.6∼214.8) from 225.1 hours (95% CI, 218∼232.0) in the control culture media (P＜0.05). The TTD did not increase with L-glutamate concentrations up to 10 g/mL, but a sig-nificant reduction in the TTD was observed in the presence of 20 g/mL L-glutamate in culture media (P＜0.05). In conclusion, selenate and L-glutamate enhance the growth of M. tuberculosis.
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