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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 205 - 210 (6page)
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초록· 키워드
오류제보하기
Salvianolic acid B, which is a compound in the Salvia miltiorrhiza, has diverse biological activities, In particular, the antioxidative effects were reported to be involved in the protection of hepatocytes, neurons, and various cell types. On the other hand, some phenolic compounds, such as ferulic acid, which is regarded as an antioxidant, plays a pro-oxidative role in the specific transitional metal environment, which could explain the anticancer effect. This study examined the pro-oxidative effects of salvianolic acid B in the presence of Cu2+. Treatment with both salvianolic acid B and Cu2+ induced the transition of supercoiled DNA to the open circular or linear form but not in the sole salvianolic acid B or Cu2+ treatments. Salvianolic acid B reduced the Cu2+ to Cu+ using neocuproine, a Cu+ specific chelator. In addition, catalase, an enzyme that breaks down the H2O2 to water and molecular oxygen, inhibited the DNA breakage. H2O2, a reactive oxygen species, has detrimental effects on biological molecules, particularly DNA. Overall, the reduction of Cu2+ by salvianolic acid B could lead to the production of H2O2 followed by DNA breakage. These results suggest that the pro-oxidative effects could be the one of the anti-cancer mechanisms of salvianolic acid B, which remains to be explained.
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참고문헌 (19)
참고문헌 신청
Halliwell B / 1999 / Antioxidant defence mechanisms: from the beginning to the end (of the beginning) / Free Radic Res 31:261~272
Deponte M / 2013 / Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes / Biochim Biophys Acta 1830:3217~3266
Rajendran P / 2014 / Antioxidants and human diseases / Clin Chim Acta 436:332~347
Murakami K / 2007 / Prooxidant action of rosmarinic acid: transition metal-dependent generation of reactive oxygen species / Toxicol In Vitro 21:613~617
Yoshino M / 2002 / Prooxidant action of gallic acid compoounds: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA / Toxicol In Vitro 16:705~709
Deponte M / 2013 / Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes / Biochim Biophys Acta 1830:3217~3266
Rajendran P / 2014 / Antioxidants and human diseases / Clin Chim Acta 436:332~347
Murakami K / 2007 / Prooxidant action of rosmarinic acid: transition metal-dependent generation of reactive oxygen species / Toxicol In Vitro 21:613~617
Yoshino M / 2002 / Prooxidant action of gallic acid compoounds: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA / Toxicol In Vitro 16:705~709
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