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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 82 - 87 (6page)
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Enterotoxigenic Bacteroides fragilis (ETBF) produces enterotoxins known to be a virulence factor. Three isotypes of the B. fragilis toxin (BFT) gene have been identified: bft-1, bft-2, and bft-3. We investigated the presence of bft isotypes in clinical B. fragilis isolates and the antimicrobial resistance of BFT-negative and BFT-positive isolates. Overall, 537 B. fragilis isolates were collected from extraintestinal specimens over 8 years (2006∼2013) from a university hospital in Korea. Samples were analyzed by multiplex PCR to identify the bft gene isotypes. Additionally, the antimicrobial susceptibility of 107 B. fragilis isolates (74 BFT-negative and 33 BFT-positive) was examined by the CLSI agar dilution method. PCR revealed a total bft gene detection rate of 30%, while 33% and 29% of blood and other extraintestinal isolates contained the gene, respectively. Among ETBF isolates, the most common isotype was bft-1 gene, followed by bft-2 and bft-3 (bft-1 77%, bft-2 14%, bft-3 9%). Resistance rates (%) for BFT-negative and positive isolates differed in response to various antimicrobial agents, with 3%, 5%, 1% and 38% of BFT-negative isolates and 3%, 6%, 3% an 42% of BFT-positive isolates being resistant to piperacillin-tazobactam, cefoxitin, imipenem, and clindamycin, respectively. Interestingly, neither BFT-negative nor positive isolates showed antimicrobial resistance to chloramphenicol and metronidazole. Overall, the proportion of ETBF from blood was similar to that of other extraintestinal sites and the bft-1 gene was the predominant isotype. Higher antimicrobial resistance rates were found in BFT-positive isolates than BFT-negative isolates, but these differences were not statistically significant.
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참고문헌 (25)
참고문헌 신청
Versalovic J / 2011 / Manual of clinical microbiology / ASM Press :858
권선영 / 2015 / Enterotoxigenic Bacteroides fragilis에 의한 질환과 검출 / 대한임상검사과학회지 47(4):161~167
Myers LL / 1987 / Isolation of enterotoxigenic Bacteroides fragilis from humans with diarrhea / J Clin Microbiol 25:2330~2333
Basset C / 2004 / Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease? / Dig Dis Sci 49:1425~1432
Toprak NU / 2006 / A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer / Clin Microbiol Infect 12:782~786
권선영 / 2015 / Enterotoxigenic Bacteroides fragilis에 의한 질환과 검출 / 대한임상검사과학회지 47(4):161~167
Myers LL / 1987 / Isolation of enterotoxigenic Bacteroides fragilis from humans with diarrhea / J Clin Microbiol 25:2330~2333
Basset C / 2004 / Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease? / Dig Dis Sci 49:1425~1432
Toprak NU / 2006 / A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer / Clin Microbiol Infect 12:782~786
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