알레르기 비염의 진단에서 MAST와 ImmunoCAP의 비교

김도윤; 박소영; 홍순비; 이오형; 최경철; 조진희

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자료유형: 학술저널

저자정보: 김도윤 박소영 홍순비 이오형 최경철 조진희

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제61권 제1호

발행연도: 2018.1

수록면: 29 - 34 (6page)

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Background and Objectives Specific IgE assays are important in the diagnosis and treatment of allergic rhinitis (AR). Among the diagnostic tests of AR, multiple allergen simultaneous test (MAST) and ImmunoCAP have been frequently used as simple, safe, and economical methods. In this study, we compared the diagnostic outcomes of MAST and ImmunoCAP in patients with AR. Subjects and Method Seventy-eight patients (52 men, 26 women, mean age 34.5 years: range 6-80 years), who have nasal symptoms of allergy and no clinical factors to influence the test results, underwent routine skin prick test (SPT) and MAST, and ImmunoCAP for eight major allergens. The diagnosis of AR was based on the criteria of SPT. The class 1 responses or more were regarded as positive for both MAST and ImmunoCAP. The agreements, sensitivities, and specificities of MAST and ImmunoCAP were evaluated along with the correlation between the two tests. Results Total agreement rates of MAST and ImmunoCAP amounted to 91.5 and 92.1%, respectively. The overall sensitivity and specificity of MAST were 73.4 and 95.3%, respectively, and those of ImmunoCAP were 81.4 and 94.5%, respectively. The correlations between MAST and ImmunoCAP showed statistical significance for Dermatophagoides pteronyssinus/Dermatophagoides farinae. Conclusion Our study demonstrated the diagnostic usefulness of both MAST and ImmunoCAP in AR, especially for the most prevalent allergens of house dust mites. Moreover, ImmunoCAP, which showed higher sensitivity than MAST, can be effectively used in rhinology clinics. Korean J Otorhinolaryngol-Head Neck Surg 2018;61(1):29-34

참고문헌 (26)

참고문헌 신청

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서민아 / 2011 / Prevalence of Allergic Diseases among Korean School-age Children: A Nationwide Cross-Sectional Questionnaire Study / Journal of Korean Medical Science 26(3):332~338

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