지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 613 - 619 (7page)
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초록· 키워드
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Hereditary hemorrhagic telangiectasia (HHT) is a hereditary, autosomal dominant, vascular dysplasia characterized by mucocutaneous telangiectasia, epistaxis, gastrointestinal bleeding, and iron deficiency anemia. Epistaxis in HHT is a recurrent and debilitating symptom, which is difficult to manage. Many methods have been tried with little success. Bevacizumab (Avastin®), a VEGF inhibitor, has been recently tried intranasally or systemically to control the recurrent epistaxis. We report three patients with HHT who were treated with intranasal bevacizumab application together with cauterization. In all three patients, recurrent epistaxis decreased considerably with improvement in quality of life. Here we describe the application methods, treatment results, and complications with literature review. We believe that this is the first report of treating epistaxis in HHT with intranasal application of bevacizumab in South Korea.
Korean J Otorhinolaryngol-Head Neck Surg 2016;59(8):613-9
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Govani FS / 2009 / Hereditary haemorrhagic telangiectasia: a clinical and scientific review / Eur J Hum Genet 17(7):860~871
Faughnan ME / 2011 / International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia / J Med Genet 48(2):73~87
Syed I / 2015 / Evidence-based management of epistaxis in hereditary haemorrhagic telangiectasia / J Laryngol Otol 129(5):410~415
Sadick H / 2005 / Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression / Haematologica 90(6):818~828
Flieger D / 2006 / Dramatic improvement in hereditary hemorrhagic telangiectasia after treatment with the vascular endothelial growth factor (VEGF) antagonist bevacizumab / Ann Hematol 85(9):631~632
Faughnan ME / 2011 / International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia / J Med Genet 48(2):73~87
Syed I / 2015 / Evidence-based management of epistaxis in hereditary haemorrhagic telangiectasia / J Laryngol Otol 129(5):410~415
Sadick H / 2005 / Patients with hereditary hemorrhagic telangiectasia have increased plasma levels of vascular endothelial growth factor and transforming growth factor-beta1 as well as high ALK1 tissue expression / Haematologica 90(6):818~828
Flieger D / 2006 / Dramatic improvement in hereditary hemorrhagic telangiectasia after treatment with the vascular endothelial growth factor (VEGF) antagonist bevacizumab / Ann Hematol 85(9):631~632
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