Evaluation of the Possible Neurotoxic Effect of the Bone Cement on the Facial Nerve: An Experimental Study

Numan Kökten; Oğuz Kadir Eğilmez; M. Tayyar Kalcıoğlu; Mustafa Baran; A. Işın Doğan Ekici

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자료유형: 학술저널

저자정보: Numan Kökten Oğuz Kadir Eğilmez M. Tayyar Kalcıoğlu Mustafa Baran A. Işın Doğan Ekici

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제11권 제3호

발행연도: 2018.1

수록면: 174 - 180 (7page)

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Objectives. To investigate neurotoxic effect of bone cement (BC) on facial nerve by using electrophysiological and histopathological methods. Methods. This study included 20 male albino Wistar rats, divided into four equal groups. Group A was designed as the control group, while group B was sham group. In the group C, BC solution was dropped onto the facial nerve trunks of rats and washed with physiological saline after 5 seconds. In the group D, BC solution was dropped onto the facial nerve trunks of rats and after allowing 5 minutes to dry, wounds were closed. Pre- and postoperative (on 4th week) evoked electromyography (EMG) measurements were done. For histopathological assessments, the rats were euthanized and tissue samples of facial nerve and surrounding areas were collected. Results. According to the wave amplitude levels of evoked EMG, postoperative amplitude levels of group D were significantly decreased, compared to preoperative amplitude levels (P=0.043). We found no statistically significant difference in inflammation among the groups. In none of the groups, foreign body reaction and granulation tissue were not detected in any of the groups. In addition, degeneration in axon, myelin, or perineural nets was not detected in any of the groups. Conclusion. This study results suggest that BC has no direct toxicity on facial nerve, while it has indirect effects, by decreasing amplitude. Therefore, we conclude that direct contact of BC with nerve should be avoided, and the area should be cleaned by aspiration or washing with physiological saline in case of contact.

참고문헌 (26)

참고문헌 신청

Righini-Grunder F / 2015 / Glass ionomer cement in otological microsurgery: experience over 16 years / Eur Arch Otorhinolaryngol 272(10):2749~2754

Hafiz G / 2005 / A more reliable method for incudostapedial rebridging ossiculoplasty: bone cement and wire / Adv Ther 22(1):56~62

Kalcioglu MT / 2013 / The use of bone cement for ossicular chain defects / Eur Arch Otorhinolaryngol 270(11):2849~2855

Kalcioglu MT / 2015 / Evaluation on shear bond strength of different glass ionomer and hydroxy apatite cements used in ossiculoplasty / Balkan Med J 32(1):23~29

Guillard O / 1997 / Biological levels of aluminium after use of aluminium-containing bone cement in post-otoneurosurgery / J Trace Elem Med Biol 11(1):53~56

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