지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 589 - 595 (7page)
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Background and Objectives Auditory neuropathy is a hearing disorder characterized by the absence or the marked impairment of the auditory brainstem responses with the preservation of the cochlear microphonics (CMs) and otoacoustic emissions. This suggests that outer hair cell (OHC) function is normal but proximal auditory function to OHCs is impaired. It is assumed that the lesion is localized at the level of the inner hair cells (IHCs), auditory nerve fibers, or the synapse between them. This study was aimed to observe the change of hearing threshold and pathology of spiral ganglion cell induced by ouabain application, and present basic data to explain the auditory neuropathy.
Materials and Method Twenty ears of twenty normal hearing cats were used in this study. Cats were treated with 100 μL ouabain (1 mM) applied on the round window. After three days, compound action potential (CAP) and CM were measured and the cochlea was obtained. Pathologic change of spiral ganglion cell was evaluated under light microscope after H&E stain. Normal saline was injected for the control group.
Results In the ouabain group, CAP threshold was increased in all tested frequencies (p＜ 0.001) and the difference of CM threshold was not significant in all frequencies (p＞0.05). There was significant difference between CAP and CM threshold shift (p＜0.001). In the control group, there was no significant difference in CAP and CM thresholds. Light microscopic findings show that the condensed chromatin and nuclear fragments of spiral ganglion cells of an ear was exposed to ouabain, and outer hair cell and inner hair cell were not damaged.
Conclusion This study shows that the CAP threshold was significantly increased but the CM threshold was not changed in the ouabain group. Ouabain induced damage of spiral ganglion cells. This study is not sufficient to explain auditory neuropathy because threshold shift of CAP is not obvious, but it would be helpful to explain that selective damage of spiral ganglion cell would be the mechanism of auditory neuropathy.
Korean J Otorhinolaryngol-Head Neck Surg 2014;57(9):589-95
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참고문헌 (18)
참고문헌 신청
Deltenre P / 1999 / Auditory neuropathy with preserved cochlear microphonics and secondary loss of otoacoustic emissions / Audiology 38 (4) : 187 ~ 195
Erichsen S / 1996 / Na,K-ATPase alpha- and beta-isoforms in the developing cochlea of the mouse / Hear Res 100 (1-2) : 143 ~ 149
Hamada M / 1999 / Morphological changes induced by administration of a Na+,K+-ATPase inhibitor in normal and hydropic inner ears of the guinea pig / Acta Otolaryngol 119 (7)
Hara Y / 1988 / Expression of sodium pump activities in BALB/c 3T3 cells transfected with cDNA encoding alpha 3-subunits of rat brain Na+,K+-ATPase / FEBS Lett 238 (1) : 27
Harrison RV / 1998 / An animal model of auditory neuropathy / Ear Hear 19 (5) : 355 ~ 361
Erichsen S / 1996 / Na,K-ATPase alpha- and beta-isoforms in the developing cochlea of the mouse / Hear Res 100 (1-2) : 143 ~ 149
Hamada M / 1999 / Morphological changes induced by administration of a Na+,K+-ATPase inhibitor in normal and hydropic inner ears of the guinea pig / Acta Otolaryngol 119 (7)
Hara Y / 1988 / Expression of sodium pump activities in BALB/c 3T3 cells transfected with cDNA encoding alpha 3-subunits of rat brain Na+,K+-ATPase / FEBS Lett 238 (1) : 27
Harrison RV / 1998 / An animal model of auditory neuropathy / Ear Hear 19 (5) : 355 ~ 361
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