전신성 홍반성 루프스 환자에서 발생하는 이과적 증상

김보영; 강명구; 안태주; 이태훈; 최재혁

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자료유형: 학술저널

저자정보: 김보영 강명구 안태주 이태훈 최재혁

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제5호

발행연도: 2008.1

수록면: 416 - 421 (6page)

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Systemic lupus erythematosus (SLE) is considered a prototype of the autoimmune disease because of its multi-organ involvement. Pathologic immune complexes and autoantibodies are the main causes of organ damage. Patients with SLE appear to be at increased risk of inner ear injury. The aim of this study was to evaluate the audiovestibular manifestations in patients with SLE. Subjects and Method：We investigated the audiovestibular manifestations of 22 patients with SLE. Pure tone audiometry and electronystagmography were performed for baseline evaluation. ESR, complement count and dsDNA were evaluated to investigate relationships between audiovestibular manifestations and disease activity of SLE. Results：Ten (45.5%) patients complained of hearing loss. Four of 10 patients were diagnosed as sensorineural hearing loss (SNHL) and 3 patients as sudden SNHL. 9 (40.9%) patients complained of vertigo. Five of 9 patients were diagnosed as peripheral vestibulopathy, 2 as central vestibulopathy and 2 showed nonspecific findings. Audiovestibular symptoms were not related with disease activity of SLE (p>0.05). Conclusion：Audiovestibular symptoms are rare but various among patients with SLE. The mechanism of ear damage remains unknown. Thus, additional prospective studies are needed to elucidate its pathogenesis. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:416-21)

#Systemic lupus erythematosus·Hearing loss·Vertigo.

참고문헌 (16)

참고문헌 신청

Andonopoulos AP / 1995 / Lygatsikas C. Sensorineural hearing disorders in systemic lupus erythematous. A controlled study / Clin Exp Rheumatol 13 (2) : 137 ~ 141

Bowman CA / 1986 / Sensorineural hearing loss associated with systemic lupus erythematosus / Otolaryngol Head Neck Surg 94 (2) : 197 ~ 204

Brooks GB / 1986 / Circulating immune complexes in Meniere’s disease / Arch Otolaryngol Head Neck Surg 94 : 197 ~ 204

Caldarelli DD / 1986 / Sensorineural hearing loss in lupus erythematosus / Am J Otol 7 (3) : 210 ~ 213

Green L / 2001 / Sudden sensorineural hearing loss as a first manifestation of systemic lupus erythematous: Association with anticardiolipin antibodies / Clin Rheumatol 20 (3

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