하인두암의 치료성적: 수술 또는 기관보존요법

태경; 신광수; 김태헌; 신지훈; 정진혁; 안태환; 전하정; 이명자

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자료유형: 학술저널

저자정보: 태경 신광수 김태헌 신지훈 정진혁 안태환 전하정 이명자

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제8호

발행연도: 2009.1

수록면: 688 - 694 (7page)

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Background and Objectives Hypopharynx cancer usually presents with late stage diseases requiring radical resection including total laryngectomy with reconstruction resulting in severe functional deficits. In order to preserve organ function, chemotherapy in combination with radiotherapy was introduced and it showed similar treatment. The aim of this study is to compare the treatment outcomes of surgery and organ preservation therapy. Subjects and Method A retrospective review of 55 patients who were diagnosed with hypopharynx cancer and underwent curative treatment from 1994 to 2006 was performed. Patients who underwent surgery or surgery plus postoperative radiotherapy were assigned to surgical treatment group and patients who underwent radiotherapy or radiotherapy with chemotherapy were assigned to organ preservation therapy group. Results Surgical treatment group consisted of 29 patients (52.7%) and organ preservation therapy group consisted of 26 patients (47.3%). The overall 5 year survival rate was 34%. The survival rate was decreased significantly according to the N stage (p=0.02). There was no statistically significant difference in 5 year survival rates between the two groups. The larynx preservation rate was 35.8% for the organ preservation therapy group and 44% for the conservation surgery group. Conclusion Treatment of hypopharynx cancer could be individualized according to the status of diseases.

#Hypopharyngeal cancer·Surgery·Organ preservation·Survival

참고문헌 (20)

참고문헌 신청

/ 1991 / Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer / N Engl J Med 324 (24) : 1685 ~ 1690

Choi EC / 2000 / Treatment results and patterns of failure after surgery for the squamous cell carcinoma of hypopharynx / Korean J Otolaryngol-Head Neck Surg 43 (5) : 528 ~

Czaja JM / 1997 / Surgical management of early-stage hypopharyngeal carcinoma / Ann Otol Rhinol Laryngol 106 (11) : 909 ~ 913

El-Deiry M / 2005 / Long-term quality of life for surgical and nonsurgical treatment of head and neck cancer / Arch Otolaryngol Head Neck Surg 131 (10) : 879 ~ 885

Forastiere AA / 2003 / Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer / N Engl J Med 349 (22) : 2091 ~ 2098

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소속기관 한양대학교

주요연구분야 의약학 > 의학 일반 의약학 > 임상의학 > 이비인후과학

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