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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제44권 제3호
발행연도
2012.1
수록면
187 - 194 (8page)

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Purpose The purpose of this study is to evaluate survival and prognostic factors for rectal cancer, including interval between surgery and radiation therapy after surgery, radiation therapy, and chemotherapy. Materials and Methods We conducted a retrospective study of 153 patients with rectal cancer who were treated with surgery, radiotherapy with/without chemotherapy at Keimyung University Dongsan Medical Center from January, 1988 to December, 2005. The study included 89 males and 64 females, with a median age of 56 years (range, 23 to 81 years). Tumor, node and metastasis (TNM) was I in 23patients, II in 39, and III in 91. Radiation therapy was performed on pelvic fields using a median dose of 54 Gy five days per week, 1.8 Gy once per day. Ninety two patients were treated with radiotherapy, 43 with concurrent chemo-radiation therapy and 18 with sequential therapy after surgery. The median follow-up period was 52 months (range, 4 to 272 months). The interval between surgery and radiation was 1-25 weeks (median, 5 weeks). Results Two-year and five-year overall survival rate was 64.7% and 46.4%, respectively. Two-year and five-year disease-free-survival (DFS) rate was 58.6% and 43.1%, respectively. Median DFS was 39 months. Loco-regional failure was evident in 10.5% of patients, 8.4% had distant metastasis,and 9.2% had both. In multivariate analysis, TNM stage and interval between surgery and radiation therapy (≤5 weeks vs. ＞5 weeks; 95% confidence interval, 1.276 to 2.877; hazard ratio, 1.916;p=0.002) were significant prognostic factors of DFS. Conclusion Survival rates for rectal cancer after surgery, chemotherapy, and radiation therapy were similar to those reported in previous studies. Starting radiation therapy as soon as possible after surgery,especially within the first five weeks after surgery, is suggested.
#Rectal neoplasms #Adjuvant radiotherapy #Drug therapy #Prognosis

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참고문헌 (23)

참고문헌 신청
/ 1985 / Prolongation of the disease-free interval in surgically treated rectal carcinoma. Gastrointestinal Tumor Study Group / N Engl J Med 312 : 1465 ~ 1472 google schola Balslev I / 1986 / Postoperative radiotherapy in Dukes' B and C carcinoma of the rectum and rectosigmoid : a randomized multicenter study / Cancer 58 : 22 ~ 28 google schola Colorectal Cancer Collaborative Group / 2001 / Adjuvant radiotherapy for rectal cancer: a systematic overview of 8,507 patients from 22 randomised trials / Lancet 358 : 1291 google schola Compton CC / 2000 / Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999 / Arch Pathol Lab Med 124 : 979 ~ 994 google schola Crucitti F / 1991 / Prognostic factors in colorectal cancer : current status and new trends / J Surg Oncol Suppl 2 : 76 ~ 82 google schola

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