재발성 성문상부암의 구제치료 결과

김지희; 이윤세; 권민수; 노종렬; 김상윤; 남순열

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자료유형: 학술저널

저자정보: 김지희 이윤세 권민수 노종렬 김상윤 남순열

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제5호

발행연도: 2009.1

수록면: 419 - 425 (7page)

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Background and Objectives：It is difficult to treat recurred supraglottic cancer safely and preserve physiologic function of the larynx. This study was designed to review the clinical manifestations of recurrent supraglottic cancer and compare the results of each salvage treatments. Subjects and Method：During the period from Jan 2000 to Sep 2007, thirty recurrent supraglottic cancers were reviewed retrospectively. Their mean follow-up period was 30.8±20.1 months. We investigated initial treatment methods, stage, recurrent sites and salvage methods, and analyzed the oncological results including disease-specific survival and overall survival. Results：Ninety-seven percent of all recurrence occurred within 3 years and 76.7% of all recurrence were diagnosed at stage III-IV when recurrence was detected. Five-year disease-specific survival rate was 28.4% and five-year overall survival rate was 73.4%. Recurrence at the primary site showed significantly better overall survival rate than that at the lymph node, primary and lymph node recurrence, or distant metastasis (p=0.008). Patients who were salvaged with total laryngectomy had significantly better disease-specific survival rate and overall survival rate (p<0.001). Conclusion：With careful selection of salvage treatment for recurrent supraglottic cancer, acceptable oncological result can be achieved. Further study for laryngeal preservation for recurrent cases is necessary.

#성문상부암·재발·구제 치료·후두절제술 #Supraglottic cancer·Recurrence·Salvage treatment·Laryngectomy

참고문헌 (14)

참고문헌 신청

Cabanillas R / 2008 / Oncologic outcomes of transoral laser surgery of supraglottic carcinoma compared with a transcervical approach / Head Neck 30 (6) : 750 ~ 755

Eckel HE / 1997 / Endoscopic laser resection of supraglottic carcinoma / Otolaryngol Head Neck Surg 117 (6) : 681 ~ 687

Forastiere AA / 2003 / Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer / N Engl J Med 349 (2) : 2091 ~ 2098

Holsinger FC / 2006 / Conservation laryngeal surgery versus total laryngectomy for radiation failure in laryngeal cancer / Head Neck 28 (9) : 779 ~ 784

Johansen LV / 2002 / Supraglottic carcinoma: Patterns of failure and salvage treatment after curatively intended radiotherapy in 410 consecutive patients / Int J Radiat Onco

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