지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.86 No.3
- 발행연도
- 2014.3
- 수록면
- 143 - 151 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Because predicting recurrence intervals and patterns would allow for appropriate therapeutic strategies, we evaluated the clinical and pathological characteristics of early and late recurrences of colorectal cancer.
Methods: Patients who developed recurrence after undergoing curative resection for colorectal cancer stage I?III between January 2000 and May 2006 were identified. Early recurrence was defined as recurrence within 2 years after primary surgery of colorectal cancer. Analyses were performed to compare the clinicopathological characteristics and overall survival rate between the early and late recurrence groups.
Results: One hundred fifty-eight patients experienced early recurrence and 64 had late recurrence. Multivariate analysis revealed that the postoperative elevation of carbohydrate antigen 19-9 (CA 19-9), venous invasion, and N stage correlated with the recurrence interval. The liver was the most common site of early recurrence (40.5%), whereas late recurrence was more common locally (28.1%), or in the lung (32.8%). The 5-year overall survival rates for early and late recurrence were significantly different (34.7% vs. 78.8%; P < 0.001). Survival rates after the surgical resection of recurrent lesions were not different between the two groups.
Conclusion: Early recurrence within 2 years after surgery was associated with poor survival outcomes after colorectal cancer recurrence. An elevated postoperative CA 19-9 level, venous invasion, and advanced N stage were found to be significant risk factors for early recurrence of colorectal cancer.
Methods: Patients who developed recurrence after undergoing curative resection for colorectal cancer stage I?III between January 2000 and May 2006 were identified. Early recurrence was defined as recurrence within 2 years after primary surgery of colorectal cancer. Analyses were performed to compare the clinicopathological characteristics and overall survival rate between the early and late recurrence groups.
Results: One hundred fifty-eight patients experienced early recurrence and 64 had late recurrence. Multivariate analysis revealed that the postoperative elevation of carbohydrate antigen 19-9 (CA 19-9), venous invasion, and N stage correlated with the recurrence interval. The liver was the most common site of early recurrence (40.5%), whereas late recurrence was more common locally (28.1%), or in the lung (32.8%). The 5-year overall survival rates for early and late recurrence were significantly different (34.7% vs. 78.8%; P < 0.001). Survival rates after the surgical resection of recurrent lesions were not different between the two groups.
Conclusion: Early recurrence within 2 years after surgery was associated with poor survival outcomes after colorectal cancer recurrence. An elevated postoperative CA 19-9 level, venous invasion, and advanced N stage were found to be significant risk factors for early recurrence of colorectal cancer.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [인터넷자원] - Ferlay J / / GLOBOCAN 2008 v2.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 /
2. [보고서] - Ministry of Health and Welfare / 2010 / The Korea central cancer registry. Annual Report of Cancer Incidence in 2008
3. [학술지(정기간행물)] - Abulafi AM. / 1994 / Local recurrence of colorectal cancer : the problem, mechanisms, management and adjuvant therapy / Br J Surg 81 : 7 ~ 19
4. [학술지(정기간행물)] - Renehan AG. / 2002 / Impact on survival of intensive follow up after curative resection for colorectal cancer : systematic review and meta-analysis of randomised trials / BMJ 324 : 813 ~
5. [학술지(정기간행물)] - Desch CE. / 2005 / Colorectal cancer surveillance : 2005 update of an American Society of Clinical Oncology practice guideline / J Clin Oncol 23 : 8512 ~ 8519
2. [보고서] - Ministry of Health and Welfare / 2010 / The Korea central cancer registry. Annual Report of Cancer Incidence in 2008
3. [학술지(정기간행물)] - Abulafi AM. / 1994 / Local recurrence of colorectal cancer : the problem, mechanisms, management and adjuvant therapy / Br J Surg 81 : 7 ~ 19
4. [학술지(정기간행물)] - Renehan AG. / 2002 / Impact on survival of intensive follow up after curative resection for colorectal cancer : systematic review and meta-analysis of randomised trials / BMJ 324 : 813 ~
5. [학술지(정기간행물)] - Desch CE. / 2005 / Colorectal cancer surveillance : 2005 update of an American Society of Clinical Oncology practice guideline / J Clin Oncol 23 : 8512 ~ 8519
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2015-510-001268637