대뇌 피질 및 피질하 청각 중추의 활성화에 미치는 MRI 스캐너 소음의 영향

김태수; Natalia Yakunina; 태우석; 강은경; 김삼수; 민지훈; 남의철

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자료유형: 학술저널

저자정보: 김태수 Natalia Yakunina 태우석 강은경 김삼수 민지훈 남의철

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제58권 제2호

발행연도: 2015.1

수록면: 101 - 109 (9page)

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Background and Objectives We compared functional MRI acquisition methods of sparse temporal acquisition (STA) and continuous acquisition (CA) to estimate the effect of MRI scanner background noise (SBN) on blood oxygen level-dependent (BOLD) activation of cortical and subcortical auditory centers during auditory stimulation. Subjects and Method Fourteen healthy subjects (eight males, age 30.6±4.7 years) were presented with classical music in a block paradigm (36 s on/off) in two STA [repitition time (TR)=12 s, 60 volumes] and two CA (TR=2 s, 360 volumes) functional MRI sessions. To account for the sample size difference, an additional volume-matched continuous dataset (CAm) was generated by matching CA to 60 volumes of STA. A group-level analysis based on BOLD activation maps was performed. Percent signal change (PSC), T-statistic values and signal variability in cortical and subcortical auditory regions of interest (ROIs) were calculated from individual activation maps and compared between the STA, CA, and CAm. Results The group analysis showed activation in the primary and secondary auditory cortices in all datasets. However, the activation of subcortical auditory centers above the accepted threshold was only observed in STA. STA (less SBN) showed higher PSCs and T-statistic values in all ROIs except planum temporale when compared to CAm. However, there was no difference in signal variability among the datasets. Conclusion Our results suggest that SBN should be considered as a significant confounder in auditory-evoked functional MRI studies particularly in the activation of subcortical auditory centers, and that STA can be an effective imaging method for reducing the effect of SBN.

#Auditory stimulation #Continuous acquisition #Functional MRI #Scanner background noise #Sparse temporal acquisition

참고문헌 (20)

참고문헌 신청

Arthurs OJ / 2000 / Linear coupling between functional magnetic resonance imaging and evoked potential amplitude in human somatosensory cortex / Neuroscience 101 (4) : 803 ~

Arthurs OJ / 2003 / What aspect of the fMRI BOLD signal best reflects the underlying electrophysiology in human somatosensory cortex? / Clin Neurophysiol 114 (7) : 1203 ~ 120

Blackman GA / 2011 / Reducing the effects of background noise during auditory functional magnetic resonance imaging of speech processing: qualitative and quantitative compar

Eden GF / 1999 / Utilizing hemodynamic delay and dispersion to detect fMRI signal change without auditory interference: the behavior interleaved gradients technique / Magn Re

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