소음 노출후 와우측벽에서 KCNJ10 K+채널의 발현양상

구본석; 김아영; 박재용; 이상희; 김진만; 김용민; 나기상; 박용호

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자료유형: 학술저널

저자정보: 구본석 김아영 박재용 이상희 김진만 김용민 나기상 박용호

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제4호

발행연도: 2008.1

수록면: 312 - 318 (7page)

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It is well known that noise exposure leads to the sensory hair cell loss and other neuronal damage in the cochlea. But recently it has been reported that noise exposure could also damage lateral wall of cochlea such as stria vascularis and spiral ligament. K+ is the major cation in endolymph and important to maintain homeostasis within the cochlea. We have investigated the expression patterns of KCNJ10 K+ channel in noise induced cochlear damage. Materials and Method： Twenty adult male guinea pigs (300-350 g) were included in this study. In experimental group (n=16), acoustic trauma was induced by continuous broad band noise for 2 hr to 115 dB SPL and broad band noise for 6 hr to 120 dB SPL with 3 consecutive days. After noise exposure, auditory brainstem response threshold shift and hair cell loss were evaluated. A study for KCNJ10 K+ channel expression was examined by immunohistochemical staining. Results：After noise exposure, auditory brainstem response showed transient threshold shift (TTS) and permanent threshold shift (PTS) in accordance with noise exposure. The expression patterns of CKNJ10 K+ channel were changeable in TTS group. But there were no change of expression patterns in PTS group. Conclusion：In the cochlear lateral wall, KCNJ10 K+ channel expressions were affected with noise exposure and these changes might be associated with the regulation of homeostasis in the cochlea lateral wall. (Korean J Otorhinolaryngol- Head Neck Surg 2008;51:312-8)

#Noise·Cochlea·KCNJ10.

참고문헌 (15)

참고문헌 신청

Benitez LD / 1972 / Temporary threshold shifts in chinchilla: Electophysiological correlates / J Acoust Soc Am 52 (4) : 1115 ~ 1123

Boettcher FA / 1995 / Distortion-product otoacoustic emissions in Mongolian gervils with resistance to noise-induced hearing loss / J Acoust Soc Am 98 (6) : 3215 ~ 3222

Crouch JJ / 1997 / Immunohistochemical localization of the Na-K-Cl cotrnaspoter(NKCC1) in the gerbil inner ear / J Histochem Cytochem 45 (6) : 773 ~ 778

Delpire E / 1999 / Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl cotransforter / Nat Genet 22 (2) : 192 ~ 195

Hibino H / 2004 / Expression of an inwardly rectifying K+ channel, Kir5.1, in specific types of fibrocytes in the cochlear lateral wall suggests its functional importance in

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구본석

소속기관 Department of Otolaryngology-Head and Neck Surgery Chungnam National University College of Medicine Daejeon Korea