지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 278 - 285 (8page)
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초록· 키워드
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Background and Objectives There are several evidences of reduced cochlea blood flow after noise exposure in the cochlea. However, the pathophysiology of blood flow change is still obscure, and endothelins, proteins that constrict blood vessels and play a key role in vascular homeostasis using its receptors may have importance in this respect. In this study, we investigated the expression changes of endothelin-1 (ET-1), endothelin receptor A (ETAR) and B (ETBR) according to auditory threshold change after noise exposure.
Materials and Method Mice were exposed to different noise to generate transient (group 2) and permanent threshold shift (group 3), respectively. Auditory threshold shifts were evaluated with auditory brainstem response and expression changes of ET-1, ETAR and ETBR after noise exposure were evaluated by immunohistochemistry and real time RT-PCR.
Results After noise exposure, the increased ET-1, ETAR and ETBR immunoreactivities were observe in stria vascularis, spiral ligament and spiral ganglion neuron. ET-1 mRNA expressions increased after noise exposure in both group 2 and group 3 compared to those of the control group. At 2 weeks after noise exposure, however, the ET-1 mRNA expressions in group 3 increased compared to that of the control but decreased compared to that of group 2. On the other hand, ETAR mRNA expression increased at 2 weeks after noise exposure in both groups, just after noise exposure in group 2 and at 2 weeks after noise exposure in group 3.
Conclusion These results suggest that expression changes of ET-1, ETAR and ETBR might be associated with hearing threshold shift and recovery after noise exposure in the cochlea.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Pacheco-Quinto J / 2013 / Endothelinconverting enzymes and related metalloproteases in Alzheimer’s disease / J Alzheimers Dis 33(Suppl 1):S101~S110
Fechter LD / 2005 / Oxidative stress: a potential basis for potentiation of noise-induced hearing loss / Environ Toxicol Pharmacol 19 (3) : 543 ~ 546
Franz P / 1997 / Endothelin-1 causes luminal constrictions in rat cochlear veins / Hear Res 112 (1-2) : 33 ~ 43
Hirose K / 2003 / Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea / J Assoc Res Otolaryngol 4 : 339 ~ 352
Hyndman KA / 2013 / Nitric oxide and the A and B of endothelin of sodium homeostasis / Curr Opin Nephrol Hypertens 22 (1) : 26 ~ 31
Fechter LD / 2005 / Oxidative stress: a potential basis for potentiation of noise-induced hearing loss / Environ Toxicol Pharmacol 19 (3) : 543 ~ 546
Franz P / 1997 / Endothelin-1 causes luminal constrictions in rat cochlear veins / Hear Res 112 (1-2) : 33 ~ 43
Hirose K / 2003 / Lateral wall histopathology and endocochlear potential in the noise-damaged mouse cochlea / J Assoc Res Otolaryngol 4 : 339 ~ 352
Hyndman KA / 2013 / Nitric oxide and the A and B of endothelin of sodium homeostasis / Curr Opin Nephrol Hypertens 22 (1) : 26 ~ 31
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