상악동 후비공 비용과 비용에서의Matrix Metalloproteinase-2/-9의 발현

민수기; 김진영; 김해영; 김현수; 홍현정; 박혜림; 전진형

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자료유형: 학술저널

저자정보: 민수기 김진영 김해영 김현수 홍현정 박혜림 전진형

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제49권 제8호

발행연도: 2006.1

수록면: 786 - 790 (5page)

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연구주제

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연구배경

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연구방법

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연구결과

초록· 키워드

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Background and Objectives：Nasal polyp (NP) and antrochoanal polyp (ACP) are soft tissue masses, featuring chronic inflammationand tissue remodeling. To elucidate the mechanism of tissue remodeling, we investigated the expressions of matrixmetalloproteinase-2 (MMP-2) and MMP-9 in ACP and NP and compared them with normal inferior turbinate mucosa. Subjectsand Method：Nasal samples, obtained from controls (n=10), from ACP (n=10) and from NP (n=13), were analysed byimmunohistochemistry. MMP-2/-9 expression was identified in epithelial, endothelial, gland, inflammatory cells. We assessedMMP-2/-9 immunoreactivity of ACP and NP in comparison with the normal inferior turbinate. The number of immunostainedinflammatory cells were determined. Results：In ACP, compared with controls, the MMP-2 expression was increased in vesselendothelium, while the MMP-9 expression was increased in vessel endothelium and inflammatory cells. In NP, compared withcontrols, increased expression of MMP-9 was observed in gland and inflammatory cells. Conclusion：ACP showed increasedexpression of MMP-2/-9, while NP showed increased expression of MMP-9. It is concluded that MMP-2/-9 in ACP and MMP-9in NP may play a role in tissue remodeling. (Korean J Otolaryngol 2006;49:786-90)

#비용·상악동 후비공 비용·MMP-2·MMP-9. #Nasal polyp·Antrochoanal polyp·MMP-2·MMP-9.

참고문헌 (14)

참고문헌 신청

/ 1995 / Imbalance between 95 kDa type IV collagenase andtissue inhibitor of metalloproteinases in sputum of patients with cysticfibrosis 152 : 765 ~ 774

/ 1997 / Migration ofeosinophils through basement membrane components in vitro:Roleof matrix metalloproteinase-9 17 : 519 ~ 528

/ 1998 / Bronchial subepithelialfibrosis and expression of matrix metalloproteinase-9 inasthmatic airway inflammation 102 : 783 ~ 788

/ 1999 / Immunohistochemical localisation ofthe matrix metalloproteinases MMP-3 and MMP-9 within the airwaysin asthma 54 : 590 ~ 596

/ 1999 / Role of matrix metalloproteinases in models of macrophagedependentacute lung injury 20 : 1145 ~ 1154

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