기니픽 나선신경절에서 소음노출 후 Erythropoietin 과 Erythropoietin Receptor 의 발현양상

김동현; 박재용; 김아영; 최진웅; 한욱경; 박용호

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자료유형: 학술저널

저자정보: 김동현 박재용 김아영 최진웅 한욱경 박용호

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제51권 제1호

발행연도: 2008.1

수록면: 16 - 21 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

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Objectives：Erythropoietin (EPO) is produced in the kidney and locally in the CNS and acts through binding to erythropoietin receptor (EPO-R). Apart from playing an essential role in erythropoiesis, recent research has shown that EPO has neurotrophic and neuroprotective functions in the CNS and found EPO and EPO-R in the inner ear. The aim of this study is to investigate distribution and expression of EPO and EPO-R in the inner ear after noise exposure. Materials and Method： Normal guinea pigs were exposed to noise. Ten of them were sacrificed at 1 hour of the noise exposure (group B) and another 10 animals were sacrificed at day 7 (group C). Four were normal controls that were not exposed to noise (Group A). Auditory function was evaluated by ABR for 7 days. Noise-induced morphological changes of cochlea were studied by phalloidin stain. The expression of EPO and EPO-R was examined by immunofluorescence. Results：The hearing threshold shift reached a level of 40 dB SPL at 8 kHz at day 1 after noise exposure and underwent a partial recovery at day 7. Increased expression of EPO and EPO-R were observed at the level of spiral ganglion cells in the noise-exposed animals. Conclusion：It is suggested that noise exposure affects the distribution and expression of EPO and EPO-R in the inner ear. (Korean J Otorhinolaryngol- Head Neck Surg 2008;51:16-21)

#Noise·Spiral ganglion·Erythropoietin·Erythropoietin receptor

참고문헌 (17)

참고문헌 신청

Bohne BA / 1976 / Mechanisms of noise damage in : the inner ear in Effects of Noise on Hearing / Raven Press : 41 ~ 70

Buemi M / 2003 / The pleiotrophic effects of erythropoietin in the central nervous system / J Neuropathol Exp Neurol 62 (3) : 228 ~ 236

Caye-Thomasen P / 2005 / Erythropoietin and erythropoietin receptor expression in the guinea pig inner ear / Hear Res 203 (1) : 21 ~ 27

Chattopadhyay A / 2000 / Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical / Biochem Pharmacol 59 (4) : 419 ~ 425

Chen YS / 2005 / Involvement of nitric oxide generation in noise-induced temporary threshold shift in guinea pigs / Hear Res 203 (1) : 94 ~ 100

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