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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 39 - 45 (7page)
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초록· 키워드
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Background and PurposeaaErythropoietin (Epo), originally recognized for its central role in
erythropoiesis, has been shown to improve the outcomes in patients with various neurological
disorders. The aim of this study was to elucidate the Epo expression pattern in the spinal cords
of Lewis rats with experimental autoimmune encephalomyelitis (EAE) and to assess the systemic
effect of Epo during the course of EAE.
MethodsaaWe used an EAE model induced in Lewis rats by immunization with myelin basic
protein. Immunized rats were given recombinant human Epo (rhEpo) intraperitoneally at a
dose of 5,000 U/kg for 7 consecutive days, either starting on day 3 post-immunization (five
rats) or on the day of clinical symptom onset (score ≥1, five rats). After immunization, the rats
were observed daily for clinical signs of EAE. Epo expression was investigated by Western
blot analysis and immunohistochemistry.
ResultsaaWestern blot analysis showed that, Epo expression was significantly elevated relative
to control in the rat spinal cord during the peak stage of EAE (p<0.05), and then decreased
thereafter. Immunohistochemistry demonstrated that Epo was expressed in some neurons and
glial cells. Epo immunoreactivity was detected in ED1-positive macrophages and astrocytes in
EAE lesions. Furthermore, we found that the intraperitoneal administration of rhEpo reduced
both the disease severity and duration of paralysis in EAE rats, and reduced macrophage activity
and increased Epo activity.
ConclusionsaaBased on these findings, we postulate that Epo expression begins to increase at
the start of EAE and that rhEpo administration leads to functional recovery from EAE paralysis.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Agnello D / 2002 / Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis / Brain Res 952 : 128 ~ 134
Brines M / 2005 / Emerging biological roles for erythropoietin in the nervous system / Nat Rev Neurosci 6 : 484 ~ 494
Brines ML / 2000 / Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury / Proc Natl Acad Sci U S A : 10526 ~ 10531
Buemi M / 2003 / The pleiotropic effects of erythropoietin in the central nervous system / J Neuropathol Exp Neurol 62 : 228 ~ 236
Chung YH / 2004 / Agerelated changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats / Brain Res 1018 : 141 ~ 146
Brines M / 2005 / Emerging biological roles for erythropoietin in the nervous system / Nat Rev Neurosci 6 : 484 ~ 494
Brines ML / 2000 / Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury / Proc Natl Acad Sci U S A : 10526 ~ 10531
Buemi M / 2003 / The pleiotropic effects of erythropoietin in the central nervous system / J Neuropathol Exp Neurol 62 : 228 ~ 236
Chung YH / 2004 / Agerelated changes in erythropoietin immunoreactivity in the cerebral cortex and hippocampus of rats / Brain Res 1018 : 141 ~ 146
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