지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 37 - 42 (6page)
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초록· 키워드
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The working mechanism of bisphosphonate on bone cells is unclear despite its powerful inhibitory activity on bone resorption. The differentiation and activation of osteoclasts are essential for bone resorption and are controlled by the stimulatory RANKL and inhibitory OPG molecules. Teeth exhibit a range of movement patterns during their eruption to establish their form and function, which inevitably accompanies peripheral bone resorption. Hence, the mandible,which contains the teeth during their eruption processes, is a good model for revealing the inhibitory mechanism of bisphosphonate upon bone resorption. In the present study,RANKL and OPG expression were examined immunohistochemically in the mandible of rats with developing teeth after alendronate administration (2.5 mg/kg). The preeruptive mandibular first molars at postnatal days 3 to 10showed the developing stages from bell to crown. No morphological changes in tooth formation were observed after alendronate administration. The number of osteoclasts in the alveolar bone around the developing teeth decreased markedly at postnatal days 3, 7 and 10 compared with the control group. RANKL induced strong positive immunohistochemical reactions in the dental follicles and stromal cells around the mandibular first molar. In particular, many osteoclasts with strongly positive reactions to RANKL appeared above the developing mandibular first molars at postnatal days 3 and 10. Immunohistochemical reactions with RANKL after alendronate administration were weaker than the control groups. However, the immunohistochemical reactivity to OPG was stronger after alendronate administration,at postnatal days 3 and 10. These results suggest that alendronate may decrease bone resorption by regulating the RANKL/OPG pathway in the process of osteoclast formation, resulting in a delay in tooth eruption.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Fleisch H / 1997 / Bisphosphonates in bone disease: From the laboratory to the patient 3rd Ed
Hofbauer LC / 2000 / The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption / J Bone Miner Res 15 (1) : 2 ~ 12
Hughes DE / 1989 / Inhibition of osteoclast-like cell formation by bisphosphonates in longterm cultures of human bone marrow / J Clin Invest 83 (6) : 1930 ~ 1935
Jilka RL / 1998 / Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption / J Clin Inves
Kawata T / 2004 / Effect of alendronate on osteoclast differentiation and bone volume in transplanted bone / Exp Anim 53 (1) : 47 ~ 51
Hofbauer LC / 2000 / The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption / J Bone Miner Res 15 (1) : 2 ~ 12
Hughes DE / 1989 / Inhibition of osteoclast-like cell formation by bisphosphonates in longterm cultures of human bone marrow / J Clin Invest 83 (6) : 1930 ~ 1935
Jilka RL / 1998 / Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption / J Clin Inves
Kawata T / 2004 / Effect of alendronate on osteoclast differentiation and bone volume in transplanted bone / Exp Anim 53 (1) : 47 ~ 51
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